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Functional Neuro-Imaging and Post-Traumatic Olfactory Impairment

OBJECTIVE: To evaluate via a research literature survey the anterior neurological significance of decreased olfactory functioning following traumatic brain injuries. MATERIALS AND METHODS: A computer literature review was performed to locate all functional neuro-imaging studies on patients with post...

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Detalles Bibliográficos
Autores principales: Roberts, Richard J., Sheehan, William, Thurber, Steven, Roberts, Mary Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122553/
https://www.ncbi.nlm.nih.gov/pubmed/21716782
http://dx.doi.org/10.4103/0253-7176.78504
Descripción
Sumario:OBJECTIVE: To evaluate via a research literature survey the anterior neurological significance of decreased olfactory functioning following traumatic brain injuries. MATERIALS AND METHODS: A computer literature review was performed to locate all functional neuro-imaging studies on patients with post-traumatic anosmia and other olfactory deficits. RESULTS: A convergence of findings from nine functional neuro-imaging studies indicating evidence for reduced metabolic activity at rest or relative hypo-perfusion during olfactory activations. Hypo-activation of the prefrontal regions was apparent in all nine post-traumatic samples, with three samples yielding evidence of reduced activity in the temporal regions as well. CONCLUSIONS: The practical ramifications include the reasonable hypothesis that a total anosmic head trauma patient likely has frontal lobe involvement.