Cargando…
The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects
BACKGROUND: We performed a retrospective longitudinal study on the effects of changes in weight, body composition, and homeostasis model assessment (HOMA) indices on glycemic progression in subjects without diabetes during a four-year follow-up period in a community cohort without intentional interv...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Diabetes Association
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122898/ https://www.ncbi.nlm.nih.gov/pubmed/21738896 http://dx.doi.org/10.4093/dmj.2011.35.2.138 |
_version_ | 1782206921191718912 |
---|---|
author | Rhee, Eun-Jung Choi, Ji-Hun Yoo, Seung-Hyun Bae, Ji-Cheol Kim, Won-Jun Choi, Eun-Suk Park, Se Eun Park, Cheol-Young Park, Seok Won Oh, Ki-Won Park, Sung-Woo Kim, Sun-Woo Lee, Won-Young |
author_facet | Rhee, Eun-Jung Choi, Ji-Hun Yoo, Seung-Hyun Bae, Ji-Cheol Kim, Won-Jun Choi, Eun-Suk Park, Se Eun Park, Cheol-Young Park, Seok Won Oh, Ki-Won Park, Sung-Woo Kim, Sun-Woo Lee, Won-Young |
author_sort | Rhee, Eun-Jung |
collection | PubMed |
description | BACKGROUND: We performed a retrospective longitudinal study on the effects of changes in weight, body composition, and homeostasis model assessment (HOMA) indices on glycemic progression in subjects without diabetes during a four-year follow-up period in a community cohort without intentional intervention. METHODS: From 28,440 non-diabetic subjects who participated in a medical check-up program in 2004, data on anthropometric and metabolic parameters were obtained after four years in 2008. Body composition analyses were performed with a bioelectrical impedance analyzer. Skeletal muscle index (SMI, %) was calculated with lean mass/weight×100. Subjects were divided into three groups according to weight change status in four years: weight loss (≤-5.0%), stable weight (-5.0 to 5.0%), weight gain (≥5.0%). Progressors were defined as the subjects who progressed to impaired fasting glucose or diabetes. RESULTS: Progressors showed worse baseline metabolic profiles compared with non-progressors. In logistic regression analyses, the increase in changes of HOMA-insulin resistance (HOMA-IR) in four years presented higher odds ratios for glycemic progression compared with other changes during that period. Among the components of body composition, a change in waist-hip ratio was the strongest predictor, and SMI change in four years was a significant negative predictor for glycemic progression. Changes in HOMA β-cell function in four years was a negative predictor for glycemic progression. CONCLUSION: Increased interval changes in HOMA-IR, weight gain and waist-hip ratio was associated with glycemic progression during a four-year period without intentional intervention in non-diabetic Korean subjects. |
format | Online Article Text |
id | pubmed-3122898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Korean Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-31228982011-07-07 The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects Rhee, Eun-Jung Choi, Ji-Hun Yoo, Seung-Hyun Bae, Ji-Cheol Kim, Won-Jun Choi, Eun-Suk Park, Se Eun Park, Cheol-Young Park, Seok Won Oh, Ki-Won Park, Sung-Woo Kim, Sun-Woo Lee, Won-Young Diabetes Metab J Original Article BACKGROUND: We performed a retrospective longitudinal study on the effects of changes in weight, body composition, and homeostasis model assessment (HOMA) indices on glycemic progression in subjects without diabetes during a four-year follow-up period in a community cohort without intentional intervention. METHODS: From 28,440 non-diabetic subjects who participated in a medical check-up program in 2004, data on anthropometric and metabolic parameters were obtained after four years in 2008. Body composition analyses were performed with a bioelectrical impedance analyzer. Skeletal muscle index (SMI, %) was calculated with lean mass/weight×100. Subjects were divided into three groups according to weight change status in four years: weight loss (≤-5.0%), stable weight (-5.0 to 5.0%), weight gain (≥5.0%). Progressors were defined as the subjects who progressed to impaired fasting glucose or diabetes. RESULTS: Progressors showed worse baseline metabolic profiles compared with non-progressors. In logistic regression analyses, the increase in changes of HOMA-insulin resistance (HOMA-IR) in four years presented higher odds ratios for glycemic progression compared with other changes during that period. Among the components of body composition, a change in waist-hip ratio was the strongest predictor, and SMI change in four years was a significant negative predictor for glycemic progression. Changes in HOMA β-cell function in four years was a negative predictor for glycemic progression. CONCLUSION: Increased interval changes in HOMA-IR, weight gain and waist-hip ratio was associated with glycemic progression during a four-year period without intentional intervention in non-diabetic Korean subjects. Korean Diabetes Association 2011-04 2011-04-30 /pmc/articles/PMC3122898/ /pubmed/21738896 http://dx.doi.org/10.4093/dmj.2011.35.2.138 Text en Copyright © 2011 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Rhee, Eun-Jung Choi, Ji-Hun Yoo, Seung-Hyun Bae, Ji-Cheol Kim, Won-Jun Choi, Eun-Suk Park, Se Eun Park, Cheol-Young Park, Seok Won Oh, Ki-Won Park, Sung-Woo Kim, Sun-Woo Lee, Won-Young The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects |
title | The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects |
title_full | The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects |
title_fullStr | The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects |
title_full_unstemmed | The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects |
title_short | The Association of Unintentional Changes in Weight, Body Composition, and Homeostasis Model Assessment Index with Glycemic Progression in Non-Diabetic Healthy Subjects |
title_sort | association of unintentional changes in weight, body composition, and homeostasis model assessment index with glycemic progression in non-diabetic healthy subjects |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122898/ https://www.ncbi.nlm.nih.gov/pubmed/21738896 http://dx.doi.org/10.4093/dmj.2011.35.2.138 |
work_keys_str_mv | AT rheeeunjung theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT choijihun theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT yooseunghyun theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT baejicheol theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT kimwonjun theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT choieunsuk theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT parkseeun theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT parkcheolyoung theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT parkseokwon theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT ohkiwon theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT parksungwoo theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT kimsunwoo theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT leewonyoung theassociationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT rheeeunjung associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT choijihun associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT yooseunghyun associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT baejicheol associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT kimwonjun associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT choieunsuk associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT parkseeun associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT parkcheolyoung associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT parkseokwon associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT ohkiwon associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT parksungwoo associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT kimsunwoo associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects AT leewonyoung associationofunintentionalchangesinweightbodycompositionandhomeostasismodelassessmentindexwithglycemicprogressioninnondiabetichealthysubjects |