Identification of the Allosteric Regulatory Site of Insulysin

BACKGROUND: Insulin degrading enzyme (IDE) is responsible for the metabolism of insulin and plays a role in clearance of the Aβ peptide associated with Alzheimer's disease. Unlike most proteolytic enzymes, IDE, which consists of four structurally related domains and exists primarily as a dimer,...

Descripción completa

Detalles Bibliográficos
Autores principales: Noinaj, Nicholas, Bhasin, Sonia K., Song, Eun Suk, Scoggin, Kirsten E., Juliano, Maria A., Juliano, Luiz, Hersh, Louis B., Rodgers, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123307/
https://www.ncbi.nlm.nih.gov/pubmed/21731629
http://dx.doi.org/10.1371/journal.pone.0020864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123307/
https://www.ncbi.nlm.nih.gov/pubmed/21731629
http://dx.doi.org/10.1371/journal.pone.0020864

Ejemplares similares