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Identification of the Allosteric Regulatory Site of Insulysin

BACKGROUND: Insulin degrading enzyme (IDE) is responsible for the metabolism of insulin and plays a role in clearance of the Aβ peptide associated with Alzheimer's disease. Unlike most proteolytic enzymes, IDE, which consists of four structurally related domains and exists primarily as a dimer,...

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Detalles Bibliográficos
Autores principales:	Noinaj, Nicholas, Bhasin, Sonia K., Song, Eun Suk, Scoggin, Kirsten E., Juliano, Maria A., Juliano, Luiz, Hersh, Louis B., Rodgers, David W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123307/ https://www.ncbi.nlm.nih.gov/pubmed/21731629 http://dx.doi.org/10.1371/journal.pone.0020864

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