Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas

BACKGROUND: HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well established Hepa-1 wild-type (WT) and HIF-1β-deficient (c4) model. These mechanisms could be clinically relevant, since HIF-1 is now...

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Detalles Bibliográficos
Autores principales: Golinska, Monika, Troy, Helen, Chung, Yuen-Li, McSheehy, Paul M, Mayr, Manuel, Yin, Xiaoke, Ly, Lucy, Williams, Kaye J, Airley, Rachel E, Harris, Adrian L, Latigo, John, Perumal, Meg, Aboagye, Eric O, Perrett, David, Stubbs, Marion, Griffiths, John R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123325/
https://www.ncbi.nlm.nih.gov/pubmed/21612605
http://dx.doi.org/10.1186/1471-2407-11-198

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