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Suppression of STAT3 and HIF-1 Alpha Mediates Anti-Angiogenic Activity of Betulinic Acid in Hypoxic PC-3 Prostate Cancer Cells

BACKGROUND: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates various cellular processes such as cell survival, angiogenesis and proliferation. In the present study, we examined that betulinic acid (BA), a triterpene from the bark of white birch, had...

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Detalles Bibliográficos
Autores principales:	Shin, Jimin, Lee, Hyo-Jeong, Jung, Deok-Beom, Jung, Ji Hoon, Lee, Hyo-Jung, Lee, Eun-Ok, Lee, Seok Geun, Shim, Beom Sang, Choi, Seung Hoon, Ko, Seong Gyu, Ahn, Kwang Seok, Jeong, Soo-Jin, Kim, Sung-Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123343/ https://www.ncbi.nlm.nih.gov/pubmed/21731766 http://dx.doi.org/10.1371/journal.pone.0021492

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