Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression

Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers. Here, with new explantation methods, we investigate...

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Detalles Bibliográficos
Autores principales: Soo, Julia K, MacKenzie Ross, Alastair D, Kallenberg, David M, Milagre, Carla, Heung Chong, W, Chow, Jade, Hill, Lucy, Hoare, Stacey, Collinson, Rebecca S, Hossain, Mehnaz, Keith, W Nicol, Marais, Richard, Bennett, Dorothy C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Signaling & Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123747/
https://www.ncbi.nlm.nih.gov/pubmed/21418545
http://dx.doi.org/10.1111/j.1755-148X.2011.00850.x

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