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Understanding emerging treatment paradigms in rheumatoid arthritis

Treatment strategies for rheumatoid arthritis (RA) will continue to evolve as new drugs are developed, as new data become available, and as our potential to achieve greater and more consistent outcomes becomes more routine. Many patients will find both symptom relief and modest control of their dise...

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Autores principales: Breedveld, Ferdinand C, Combe, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123964/
https://www.ncbi.nlm.nih.gov/pubmed/21624182
http://dx.doi.org/10.1186/1478-6354-13-S1-S3
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author Breedveld, Ferdinand C
Combe, Bernard
author_facet Breedveld, Ferdinand C
Combe, Bernard
author_sort Breedveld, Ferdinand C
collection PubMed
description Treatment strategies for rheumatoid arthritis (RA) will continue to evolve as new drugs are developed, as new data become available, and as our potential to achieve greater and more consistent outcomes becomes more routine. Many patients will find both symptom relief and modest control of their disease with disease-modifying antirheumatic drugs (DMARDs), yet this course of therapy is clearly not effective in all patients. In fact, despite strong evidence that intensive treatment in the early stages of RA can slow or stop disease progression and may prevent disability, many patients continue to be managed in a stepwise manner and are treated with an ongoing monotherapy regimen with DMARDs. There is now a large body of evidence demonstrating the success of treating RA patients with anti-TNF therapy, usually in combination with methotrexate. As a result of the increased use of anti-TNF therapy, treatment paradigms have changed – and our practice is beginning to reflect this change. In the present review, we summarize the salient points of several recently proposed and emerging treatment paradigms with an emphasis on how these strategies may impact future practice.
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spelling pubmed-31239642011-06-28 Understanding emerging treatment paradigms in rheumatoid arthritis Breedveld, Ferdinand C Combe, Bernard Arthritis Res Ther Review Treatment strategies for rheumatoid arthritis (RA) will continue to evolve as new drugs are developed, as new data become available, and as our potential to achieve greater and more consistent outcomes becomes more routine. Many patients will find both symptom relief and modest control of their disease with disease-modifying antirheumatic drugs (DMARDs), yet this course of therapy is clearly not effective in all patients. In fact, despite strong evidence that intensive treatment in the early stages of RA can slow or stop disease progression and may prevent disability, many patients continue to be managed in a stepwise manner and are treated with an ongoing monotherapy regimen with DMARDs. There is now a large body of evidence demonstrating the success of treating RA patients with anti-TNF therapy, usually in combination with methotrexate. As a result of the increased use of anti-TNF therapy, treatment paradigms have changed – and our practice is beginning to reflect this change. In the present review, we summarize the salient points of several recently proposed and emerging treatment paradigms with an emphasis on how these strategies may impact future practice. BioMed Central 2011 2011-05-25 /pmc/articles/PMC3123964/ /pubmed/21624182 http://dx.doi.org/10.1186/1478-6354-13-S1-S3 Text en Copyright ©2011 Breedveld and Combe; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Breedveld, Ferdinand C
Combe, Bernard
Understanding emerging treatment paradigms in rheumatoid arthritis
title Understanding emerging treatment paradigms in rheumatoid arthritis
title_full Understanding emerging treatment paradigms in rheumatoid arthritis
title_fullStr Understanding emerging treatment paradigms in rheumatoid arthritis
title_full_unstemmed Understanding emerging treatment paradigms in rheumatoid arthritis
title_short Understanding emerging treatment paradigms in rheumatoid arthritis
title_sort understanding emerging treatment paradigms in rheumatoid arthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123964/
https://www.ncbi.nlm.nih.gov/pubmed/21624182
http://dx.doi.org/10.1186/1478-6354-13-S1-S3
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