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Understanding emerging treatment paradigms in rheumatoid arthritis
Treatment strategies for rheumatoid arthritis (RA) will continue to evolve as new drugs are developed, as new data become available, and as our potential to achieve greater and more consistent outcomes becomes more routine. Many patients will find both symptom relief and modest control of their dise...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123964/ https://www.ncbi.nlm.nih.gov/pubmed/21624182 http://dx.doi.org/10.1186/1478-6354-13-S1-S3 |
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author | Breedveld, Ferdinand C Combe, Bernard |
author_facet | Breedveld, Ferdinand C Combe, Bernard |
author_sort | Breedveld, Ferdinand C |
collection | PubMed |
description | Treatment strategies for rheumatoid arthritis (RA) will continue to evolve as new drugs are developed, as new data become available, and as our potential to achieve greater and more consistent outcomes becomes more routine. Many patients will find both symptom relief and modest control of their disease with disease-modifying antirheumatic drugs (DMARDs), yet this course of therapy is clearly not effective in all patients. In fact, despite strong evidence that intensive treatment in the early stages of RA can slow or stop disease progression and may prevent disability, many patients continue to be managed in a stepwise manner and are treated with an ongoing monotherapy regimen with DMARDs. There is now a large body of evidence demonstrating the success of treating RA patients with anti-TNF therapy, usually in combination with methotrexate. As a result of the increased use of anti-TNF therapy, treatment paradigms have changed – and our practice is beginning to reflect this change. In the present review, we summarize the salient points of several recently proposed and emerging treatment paradigms with an emphasis on how these strategies may impact future practice. |
format | Online Article Text |
id | pubmed-3123964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31239642011-06-28 Understanding emerging treatment paradigms in rheumatoid arthritis Breedveld, Ferdinand C Combe, Bernard Arthritis Res Ther Review Treatment strategies for rheumatoid arthritis (RA) will continue to evolve as new drugs are developed, as new data become available, and as our potential to achieve greater and more consistent outcomes becomes more routine. Many patients will find both symptom relief and modest control of their disease with disease-modifying antirheumatic drugs (DMARDs), yet this course of therapy is clearly not effective in all patients. In fact, despite strong evidence that intensive treatment in the early stages of RA can slow or stop disease progression and may prevent disability, many patients continue to be managed in a stepwise manner and are treated with an ongoing monotherapy regimen with DMARDs. There is now a large body of evidence demonstrating the success of treating RA patients with anti-TNF therapy, usually in combination with methotrexate. As a result of the increased use of anti-TNF therapy, treatment paradigms have changed – and our practice is beginning to reflect this change. In the present review, we summarize the salient points of several recently proposed and emerging treatment paradigms with an emphasis on how these strategies may impact future practice. BioMed Central 2011 2011-05-25 /pmc/articles/PMC3123964/ /pubmed/21624182 http://dx.doi.org/10.1186/1478-6354-13-S1-S3 Text en Copyright ©2011 Breedveld and Combe; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Breedveld, Ferdinand C Combe, Bernard Understanding emerging treatment paradigms in rheumatoid arthritis |
title | Understanding emerging treatment paradigms in rheumatoid arthritis |
title_full | Understanding emerging treatment paradigms in rheumatoid arthritis |
title_fullStr | Understanding emerging treatment paradigms in rheumatoid arthritis |
title_full_unstemmed | Understanding emerging treatment paradigms in rheumatoid arthritis |
title_short | Understanding emerging treatment paradigms in rheumatoid arthritis |
title_sort | understanding emerging treatment paradigms in rheumatoid arthritis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123964/ https://www.ncbi.nlm.nih.gov/pubmed/21624182 http://dx.doi.org/10.1186/1478-6354-13-S1-S3 |
work_keys_str_mv | AT breedveldferdinandc understandingemergingtreatmentparadigmsinrheumatoidarthritis AT combebernard understandingemergingtreatmentparadigmsinrheumatoidarthritis |