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Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities
Metabolic and neurodegenerative disorders have a growing prevalence in Western countries. Available epidemiologic and neurobiological evidences support the existence of a pathophysiological link between these conditions. Glucagon-like peptide 1 (GLP-1), whose activity is reduced in insulin resistanc...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124026/ https://www.ncbi.nlm.nih.gov/pubmed/21747826 http://dx.doi.org/10.1155/2011/281674 |
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author | Mossello, Enrico Ballini, Elena Boncinelli, Marta Monami, Matteo Lonetto, Giuseppe Mello, Anna Maria Tarantini, Francesca Baldasseroni, Samuele Mannucci, Edoardo Marchionni, Niccolò |
author_facet | Mossello, Enrico Ballini, Elena Boncinelli, Marta Monami, Matteo Lonetto, Giuseppe Mello, Anna Maria Tarantini, Francesca Baldasseroni, Samuele Mannucci, Edoardo Marchionni, Niccolò |
author_sort | Mossello, Enrico |
collection | PubMed |
description | Metabolic and neurodegenerative disorders have a growing prevalence in Western countries. Available epidemiologic and neurobiological evidences support the existence of a pathophysiological link between these conditions. Glucagon-like peptide 1 (GLP-1), whose activity is reduced in insulin resistance, has been implicated in central nervous system function, including cognition, synaptic plasticity, and neurogenesis. We review the experimental researches suggesting that GLP-1 dysfunction might be a mediating factor between Type 2 diabetes mellitus (T2DM) and neurodegeneration. Drug treatments enhancing GLP-1 activity hold out hope for treatment and prevention of Alzheimer's disease (AD) and cognitive decline. |
format | Online Article Text |
id | pubmed-3124026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31240262011-07-11 Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities Mossello, Enrico Ballini, Elena Boncinelli, Marta Monami, Matteo Lonetto, Giuseppe Mello, Anna Maria Tarantini, Francesca Baldasseroni, Samuele Mannucci, Edoardo Marchionni, Niccolò Exp Diabetes Res Review Article Metabolic and neurodegenerative disorders have a growing prevalence in Western countries. Available epidemiologic and neurobiological evidences support the existence of a pathophysiological link between these conditions. Glucagon-like peptide 1 (GLP-1), whose activity is reduced in insulin resistance, has been implicated in central nervous system function, including cognition, synaptic plasticity, and neurogenesis. We review the experimental researches suggesting that GLP-1 dysfunction might be a mediating factor between Type 2 diabetes mellitus (T2DM) and neurodegeneration. Drug treatments enhancing GLP-1 activity hold out hope for treatment and prevention of Alzheimer's disease (AD) and cognitive decline. Hindawi Publishing Corporation 2011 2011-06-01 /pmc/articles/PMC3124026/ /pubmed/21747826 http://dx.doi.org/10.1155/2011/281674 Text en Copyright © 2011 Enrico Mossello et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Mossello, Enrico Ballini, Elena Boncinelli, Marta Monami, Matteo Lonetto, Giuseppe Mello, Anna Maria Tarantini, Francesca Baldasseroni, Samuele Mannucci, Edoardo Marchionni, Niccolò Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities |
title | Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities |
title_full | Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities |
title_fullStr | Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities |
title_full_unstemmed | Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities |
title_short | Glucagon-Like Peptide-1, Diabetes, and Cognitive Decline: Possible Pathophysiological Links and Therapeutic Opportunities |
title_sort | glucagon-like peptide-1, diabetes, and cognitive decline: possible pathophysiological links and therapeutic opportunities |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124026/ https://www.ncbi.nlm.nih.gov/pubmed/21747826 http://dx.doi.org/10.1155/2011/281674 |
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