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Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias

Vertebrate haematopoietic stem cells (HSCs) give rise to a hierarchically organised set of progenitors for erythroid, myeloid, lymphoid and megakaryocyte lineages, and are responsible for lifelong maintenance of the blood system. Dysregulation of the haematopoietic differentiation programme is at th...

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Detalles Bibliográficos
Autores principales: Crozatier, Michèle, Vincent, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124048/
https://www.ncbi.nlm.nih.gov/pubmed/21669932
http://dx.doi.org/10.1242/dmm.007351
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author Crozatier, Michèle
Vincent, Alain
author_facet Crozatier, Michèle
Vincent, Alain
author_sort Crozatier, Michèle
collection PubMed
description Vertebrate haematopoietic stem cells (HSCs) give rise to a hierarchically organised set of progenitors for erythroid, myeloid, lymphoid and megakaryocyte lineages, and are responsible for lifelong maintenance of the blood system. Dysregulation of the haematopoietic differentiation programme is at the origin of numerous pathologies, including leukaemias. With the discoveries that many transcriptional regulators and signalling pathways controlling blood cell development are conserved between humans and Drosophila melanogaster, the fruit fly has become a good model for investigating the mechanisms underlying the generation of blood cell lineages and blood cell homeostasis. In this review article, we discuss how genetic and molecular studies of Drosophila haematopoiesis can contribute to our understanding of the haematopoietic niche, as well as of the origin and/or progression of haematopoietic malignancies in humans.
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spelling pubmed-31240482011-07-02 Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias Crozatier, Michèle Vincent, Alain Dis Model Mech Primer Vertebrate haematopoietic stem cells (HSCs) give rise to a hierarchically organised set of progenitors for erythroid, myeloid, lymphoid and megakaryocyte lineages, and are responsible for lifelong maintenance of the blood system. Dysregulation of the haematopoietic differentiation programme is at the origin of numerous pathologies, including leukaemias. With the discoveries that many transcriptional regulators and signalling pathways controlling blood cell development are conserved between humans and Drosophila melanogaster, the fruit fly has become a good model for investigating the mechanisms underlying the generation of blood cell lineages and blood cell homeostasis. In this review article, we discuss how genetic and molecular studies of Drosophila haematopoiesis can contribute to our understanding of the haematopoietic niche, as well as of the origin and/or progression of haematopoietic malignancies in humans. The Company of Biologists Limited 2011-07 2011-06-13 /pmc/articles/PMC3124048/ /pubmed/21669932 http://dx.doi.org/10.1242/dmm.007351 Text en © 2011. Published by The Company of Biologists Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.
spellingShingle Primer
Crozatier, Michèle
Vincent, Alain
Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias
title Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias
title_full Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias
title_fullStr Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias
title_full_unstemmed Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias
title_short Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias
title_sort drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124048/
https://www.ncbi.nlm.nih.gov/pubmed/21669932
http://dx.doi.org/10.1242/dmm.007351
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