Cargando…
Effective Therapy Using Voglibose for Nonalcoholic Steatohepatitis in a Patient with Insufficient Dietary and Exercise Therapy: Exploring Other Treatment Possibilities
A 56-year-old Japanese female with a 10-year history of thyroiditis presented to our institution. The laboratory data and clinical findings suggested that the patient had complicated nonalcoholic fatty liver disease or nonalcoholic steatohepatitis (NASH) with autoimmune hepatitis according to the cr...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124327/ https://www.ncbi.nlm.nih.gov/pubmed/21712950 http://dx.doi.org/10.1159/000329346 |
_version_ | 1782207075859824640 |
---|---|
author | Nagai, Kazuki Matsumaru, Katsuhiko Takahashi, Yutaka Nakamura, Noriko |
author_facet | Nagai, Kazuki Matsumaru, Katsuhiko Takahashi, Yutaka Nakamura, Noriko |
author_sort | Nagai, Kazuki |
collection | PubMed |
description | A 56-year-old Japanese female with a 10-year history of thyroiditis presented to our institution. The laboratory data and clinical findings suggested that the patient had complicated nonalcoholic fatty liver disease or nonalcoholic steatohepatitis (NASH) with autoimmune hepatitis according to the criteria by the application of the International Autoimmune Hepatitis score. The patient could not manage by herself so dietary- and exercise-based treatment was difficult. Accordingly, ursodeoxycholic acid and ezetimibe therapy was started and continued until the performance of a liver needle biopsy to define the diagnosis. However, no improvement in liver function was observed. In addition, pathological findings indicated that the patient had NASH. The patient was finally diagnosed as having NASH. Therefore, voglibose was added to the ursodeoxycholic acid and ezetimibe therapy, and this addition of voglibose actually took effect. The patient's serum aspartate transaminase and alanine aminotransferase levels decreased dramatically. This report is the first to document other treatment possibilities of NASH in a case when dietary therapy is difficult. |
format | Online Article Text |
id | pubmed-3124327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-31243272011-06-27 Effective Therapy Using Voglibose for Nonalcoholic Steatohepatitis in a Patient with Insufficient Dietary and Exercise Therapy: Exploring Other Treatment Possibilities Nagai, Kazuki Matsumaru, Katsuhiko Takahashi, Yutaka Nakamura, Noriko Case Rep Gastroenterol Published: June 2011 A 56-year-old Japanese female with a 10-year history of thyroiditis presented to our institution. The laboratory data and clinical findings suggested that the patient had complicated nonalcoholic fatty liver disease or nonalcoholic steatohepatitis (NASH) with autoimmune hepatitis according to the criteria by the application of the International Autoimmune Hepatitis score. The patient could not manage by herself so dietary- and exercise-based treatment was difficult. Accordingly, ursodeoxycholic acid and ezetimibe therapy was started and continued until the performance of a liver needle biopsy to define the diagnosis. However, no improvement in liver function was observed. In addition, pathological findings indicated that the patient had NASH. The patient was finally diagnosed as having NASH. Therefore, voglibose was added to the ursodeoxycholic acid and ezetimibe therapy, and this addition of voglibose actually took effect. The patient's serum aspartate transaminase and alanine aminotransferase levels decreased dramatically. This report is the first to document other treatment possibilities of NASH in a case when dietary therapy is difficult. S. Karger AG 2011-06-10 /pmc/articles/PMC3124327/ /pubmed/21712950 http://dx.doi.org/10.1159/000329346 Text en Copyright © 2011 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published: June 2011 Nagai, Kazuki Matsumaru, Katsuhiko Takahashi, Yutaka Nakamura, Noriko Effective Therapy Using Voglibose for Nonalcoholic Steatohepatitis in a Patient with Insufficient Dietary and Exercise Therapy: Exploring Other Treatment Possibilities |
title | Effective Therapy Using Voglibose for Nonalcoholic Steatohepatitis in a Patient with Insufficient Dietary and Exercise Therapy: Exploring Other Treatment Possibilities |
title_full | Effective Therapy Using Voglibose for Nonalcoholic Steatohepatitis in a Patient with Insufficient Dietary and Exercise Therapy: Exploring Other Treatment Possibilities |
title_fullStr | Effective Therapy Using Voglibose for Nonalcoholic Steatohepatitis in a Patient with Insufficient Dietary and Exercise Therapy: Exploring Other Treatment Possibilities |
title_full_unstemmed | Effective Therapy Using Voglibose for Nonalcoholic Steatohepatitis in a Patient with Insufficient Dietary and Exercise Therapy: Exploring Other Treatment Possibilities |
title_short | Effective Therapy Using Voglibose for Nonalcoholic Steatohepatitis in a Patient with Insufficient Dietary and Exercise Therapy: Exploring Other Treatment Possibilities |
title_sort | effective therapy using voglibose for nonalcoholic steatohepatitis in a patient with insufficient dietary and exercise therapy: exploring other treatment possibilities |
topic | Published: June 2011 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124327/ https://www.ncbi.nlm.nih.gov/pubmed/21712950 http://dx.doi.org/10.1159/000329346 |
work_keys_str_mv | AT nagaikazuki effectivetherapyusingvoglibosefornonalcoholicsteatohepatitisinapatientwithinsufficientdietaryandexercisetherapyexploringothertreatmentpossibilities AT matsumarukatsuhiko effectivetherapyusingvoglibosefornonalcoholicsteatohepatitisinapatientwithinsufficientdietaryandexercisetherapyexploringothertreatmentpossibilities AT takahashiyutaka effectivetherapyusingvoglibosefornonalcoholicsteatohepatitisinapatientwithinsufficientdietaryandexercisetherapyexploringothertreatmentpossibilities AT nakamuranoriko effectivetherapyusingvoglibosefornonalcoholicsteatohepatitisinapatientwithinsufficientdietaryandexercisetherapyexploringothertreatmentpossibilities |