Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure

BACKGROUND: The WNT4 gene plays an important role in female sex determination and differentiation. It also contributes to maintaining of the ovaries and the survival of follicles. METHODS: We sequenced the coding region and splice sites of WNT4 in 145 Han Chinese women with premature ovarian failure...

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Autores principales: Chen, Beili, Suo, Peisu, Wang, Binbin, Wang, Jing, Yang, Lu, Zhou, Sirui, Zhu, Ying, Ma, Xu, Cao, Yunxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124426/
https://www.ncbi.nlm.nih.gov/pubmed/21624127
http://dx.doi.org/10.1186/1477-7827-9-75
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author Chen, Beili
Suo, Peisu
Wang, Binbin
Wang, Jing
Yang, Lu
Zhou, Sirui
Zhu, Ying
Ma, Xu
Cao, Yunxia
author_facet Chen, Beili
Suo, Peisu
Wang, Binbin
Wang, Jing
Yang, Lu
Zhou, Sirui
Zhu, Ying
Ma, Xu
Cao, Yunxia
author_sort Chen, Beili
collection PubMed
description BACKGROUND: The WNT4 gene plays an important role in female sex determination and differentiation. It also contributes to maintaining of the ovaries and the survival of follicles. METHODS: We sequenced the coding region and splice sites of WNT4 in 145 Han Chinese women with premature ovarian failure (POF) and 200 healthy controls. RESULTS: Only one novel variation, in Exon 2 (195C > T), was detected among the women with POF. However, this synonymous variation did not result in a change in amino acid sequence (65 Asp > Asp). No further variants were found in any of the samples. CONCLUSION: Although we cannot provide any evidence that it is a possible disease-causing gene, this study is the first attempt to investigate the possible role of WNT4 in Han Chinese women with POF.
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spelling pubmed-31244262011-06-28 Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure Chen, Beili Suo, Peisu Wang, Binbin Wang, Jing Yang, Lu Zhou, Sirui Zhu, Ying Ma, Xu Cao, Yunxia Reprod Biol Endocrinol Methodology BACKGROUND: The WNT4 gene plays an important role in female sex determination and differentiation. It also contributes to maintaining of the ovaries and the survival of follicles. METHODS: We sequenced the coding region and splice sites of WNT4 in 145 Han Chinese women with premature ovarian failure (POF) and 200 healthy controls. RESULTS: Only one novel variation, in Exon 2 (195C > T), was detected among the women with POF. However, this synonymous variation did not result in a change in amino acid sequence (65 Asp > Asp). No further variants were found in any of the samples. CONCLUSION: Although we cannot provide any evidence that it is a possible disease-causing gene, this study is the first attempt to investigate the possible role of WNT4 in Han Chinese women with POF. BioMed Central 2011-05-30 /pmc/articles/PMC3124426/ /pubmed/21624127 http://dx.doi.org/10.1186/1477-7827-9-75 Text en Copyright ©2011 Chen et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Methodology
Chen, Beili
Suo, Peisu
Wang, Binbin
Wang, Jing
Yang, Lu
Zhou, Sirui
Zhu, Ying
Ma, Xu
Cao, Yunxia
Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure
title Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure
title_full Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure
title_fullStr Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure
title_full_unstemmed Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure
title_short Mutation analysis of the WNT4 gene in Han Chinese women with premature ovarian failure
title_sort mutation analysis of the wnt4 gene in han chinese women with premature ovarian failure
topic Methodology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124426/
https://www.ncbi.nlm.nih.gov/pubmed/21624127
http://dx.doi.org/10.1186/1477-7827-9-75
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