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Genomic Organization of H2Av Containing Nucleosomes in Drosophila Heterochromatin
H2Av is a versatile histone variant that plays both positive and negative roles in transcription, DNA repair, and chromatin structure in Drosophila. H2Av, and its broader homolog H2A.Z, tend to be enriched toward 5′ ends of genes, and exist in both euchromatin and heterochromatin. Its organization a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124471/ https://www.ncbi.nlm.nih.gov/pubmed/21738578 http://dx.doi.org/10.1371/journal.pone.0020511 |
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author | Zhang, Zhenhai Pugh, B. Franklin |
author_facet | Zhang, Zhenhai Pugh, B. Franklin |
author_sort | Zhang, Zhenhai |
collection | PubMed |
description | H2Av is a versatile histone variant that plays both positive and negative roles in transcription, DNA repair, and chromatin structure in Drosophila. H2Av, and its broader homolog H2A.Z, tend to be enriched toward 5′ ends of genes, and exist in both euchromatin and heterochromatin. Its organization around euchromatin genes and other features have been described in many eukaryotic model organisms. However, less is known about H2Av nucleosome organization in heterochromatin. Here we report the properties and organization of individual H2Av nucleosomes around genes and transposable elements located in Drosophila heterochromatic regions. We compare the similarity and differences with that found in euchromatic regions. Our analyses suggest that nucleosomes are intrinsically positioned on inverted repeats of DNA transposable elements such as those related to the “1360” element, but are not intrinsically positioned on retrotransposon-related elements. |
format | Online Article Text |
id | pubmed-3124471 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31244712011-07-07 Genomic Organization of H2Av Containing Nucleosomes in Drosophila Heterochromatin Zhang, Zhenhai Pugh, B. Franklin PLoS One Research Article H2Av is a versatile histone variant that plays both positive and negative roles in transcription, DNA repair, and chromatin structure in Drosophila. H2Av, and its broader homolog H2A.Z, tend to be enriched toward 5′ ends of genes, and exist in both euchromatin and heterochromatin. Its organization around euchromatin genes and other features have been described in many eukaryotic model organisms. However, less is known about H2Av nucleosome organization in heterochromatin. Here we report the properties and organization of individual H2Av nucleosomes around genes and transposable elements located in Drosophila heterochromatic regions. We compare the similarity and differences with that found in euchromatic regions. Our analyses suggest that nucleosomes are intrinsically positioned on inverted repeats of DNA transposable elements such as those related to the “1360” element, but are not intrinsically positioned on retrotransposon-related elements. Public Library of Science 2011-06-27 /pmc/articles/PMC3124471/ /pubmed/21738578 http://dx.doi.org/10.1371/journal.pone.0020511 Text en Zhang, Pugh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zhang, Zhenhai Pugh, B. Franklin Genomic Organization of H2Av Containing Nucleosomes in Drosophila Heterochromatin |
title | Genomic Organization of H2Av Containing Nucleosomes in Drosophila Heterochromatin |
title_full | Genomic Organization of H2Av Containing Nucleosomes in Drosophila Heterochromatin |
title_fullStr | Genomic Organization of H2Av Containing Nucleosomes in Drosophila Heterochromatin |
title_full_unstemmed | Genomic Organization of H2Av Containing Nucleosomes in Drosophila Heterochromatin |
title_short | Genomic Organization of H2Av Containing Nucleosomes in Drosophila Heterochromatin |
title_sort | genomic organization of h2av containing nucleosomes in drosophila heterochromatin |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124471/ https://www.ncbi.nlm.nih.gov/pubmed/21738578 http://dx.doi.org/10.1371/journal.pone.0020511 |
work_keys_str_mv | AT zhangzhenhai genomicorganizationofh2avcontainingnucleosomesindrosophilaheterochromatin AT pughbfranklin genomicorganizationofh2avcontainingnucleosomesindrosophilaheterochromatin |