Discordant Gene Expression Signatures and Related Phenotypic Differences in Lamin A- and A/C-Related Hutchinson-Gilford Progeria Syndrome (HGPS)

Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disorder displaying features reminiscent of premature senescence caused by germline mutations in the LMNA gene encoding lamin A and C, essential components of the nuclear lamina. By studying a family with homozygous LMNA mutation (K542N), we s...

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Detalles Bibliográficos
Autores principales: Plasilova, Martina, Chattopadhyay, Chandon, Ghosh, Apurba, Wenzel, Friedel, Demougin, Philippe, Noppen, Christoph, Schaub, Nathalie, Szinnai, Gabor, Terracciano, Luigi, Heinimann, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124505/
https://www.ncbi.nlm.nih.gov/pubmed/21738662
http://dx.doi.org/10.1371/journal.pone.0021433

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