Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity

It has been recently suggested that resveratrol can be effective in slowing down Alzheimer's disease (AD) development. As reported in many biochemical studies, resveratrol seems to exert its neuro-protective role through inhibition of β-amyloid aggregation (Aβ), by scavenging oxidants and exert...

Descripción completa

Detalles Bibliográficos
Autores principales: Granzotto, Alberto, Zatta, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124535/
https://www.ncbi.nlm.nih.gov/pubmed/21738712
http://dx.doi.org/10.1371/journal.pone.0021565
_version_ 1782207106768699392
author Granzotto, Alberto
Zatta, Paolo
author_facet Granzotto, Alberto
Zatta, Paolo
author_sort Granzotto, Alberto
collection PubMed
description It has been recently suggested that resveratrol can be effective in slowing down Alzheimer's disease (AD) development. As reported in many biochemical studies, resveratrol seems to exert its neuro-protective role through inhibition of β-amyloid aggregation (Aβ), by scavenging oxidants and exerting anti-inflammatory activities. In this paper, we demonstrate that resveratrol is cytoprotective in human neuroblastoma cells exposed to Aβ and or to Aβ-metal complex. Our findings suggest that resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties.
format Online
Article
Text
id pubmed-3124535
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-31245352011-07-07 Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity Granzotto, Alberto Zatta, Paolo PLoS One Research Article It has been recently suggested that resveratrol can be effective in slowing down Alzheimer's disease (AD) development. As reported in many biochemical studies, resveratrol seems to exert its neuro-protective role through inhibition of β-amyloid aggregation (Aβ), by scavenging oxidants and exerting anti-inflammatory activities. In this paper, we demonstrate that resveratrol is cytoprotective in human neuroblastoma cells exposed to Aβ and or to Aβ-metal complex. Our findings suggest that resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties. Public Library of Science 2011-06-27 /pmc/articles/PMC3124535/ /pubmed/21738712 http://dx.doi.org/10.1371/journal.pone.0021565 Text en Granzotto, Zatta. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Granzotto, Alberto
Zatta, Paolo
Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity
title Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity
title_full Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity
title_fullStr Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity
title_full_unstemmed Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity
title_short Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity
title_sort resveratrol acts not through anti-aggregative pathways but mainly via its scavenging properties against aβ and aβ-metal complexes toxicity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124535/
https://www.ncbi.nlm.nih.gov/pubmed/21738712
http://dx.doi.org/10.1371/journal.pone.0021565
work_keys_str_mv AT granzottoalberto resveratrolactsnotthroughantiaggregativepathwaysbutmainlyviaitsscavengingpropertiesagainstabandabmetalcomplexestoxicity
AT zattapaolo resveratrolactsnotthroughantiaggregativepathwaysbutmainlyviaitsscavengingpropertiesagainstabandabmetalcomplexestoxicity

Ejemplares similares