Amitriptyline-Mediated Cognitive Enhancement in Aged 3×Tg Alzheimer's Disease Mice Is Associated with Neurogenesis and Neurotrophic Activity

Approximately 35 million people worldwide suffer from Alzheimer's disease (AD). Existing therapeutics, while moderately effective, are currently unable to stem the widespread rise in AD prevalence. AD is associated with an increase in amyloid beta (Aβ) oligomers and hyperphosphorylated tau, alo...

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Detalles Bibliográficos
Autores principales: Chadwick, Wayne, Mitchell, Nick, Caroll, Jenna, Zhou, Yu, Park, Sung-Soo, Wang, Liyun, Becker, Kevin G., Zhang, Yongqing, Lehrmann, Elin, Wood, William H., Martin, Bronwen, Maudsley, Stuart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124550/
https://www.ncbi.nlm.nih.gov/pubmed/21738757
http://dx.doi.org/10.1371/journal.pone.0021660

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