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Arginase and Arginine Dysregulation in Asthma
In recent years, evidence has accumulated indicating that the enzyme arginase, which converts L-arginine into L-ornithine and urea, plays a key role in the pathogenesis of pulmonary disorders such as asthma through dysregulation of L-arginine metabolism and modulation of nitric oxide (NO) homeostasi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124954/ https://www.ncbi.nlm.nih.gov/pubmed/21747870 http://dx.doi.org/10.1155/2011/736319 |
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author | Benson, Renée C. Hardy, Karen A. Morris, Claudia R. |
author_facet | Benson, Renée C. Hardy, Karen A. Morris, Claudia R. |
author_sort | Benson, Renée C. |
collection | PubMed |
description | In recent years, evidence has accumulated indicating that the enzyme arginase, which converts L-arginine into L-ornithine and urea, plays a key role in the pathogenesis of pulmonary disorders such as asthma through dysregulation of L-arginine metabolism and modulation of nitric oxide (NO) homeostasis. Allergic asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Through substrate competition, arginase decreases bioavailability of L-arginine for nitric oxide synthase (NOS), thereby limiting NO production with subsequent effects on airway tone and inflammation. By decreasing L-arginine bioavailability, arginase may also contribute to the uncoupling of NOS and the formation of the proinflammatory oxidant peroxynitrite in the airways. Finally, arginase may play a role in the development of chronic airway remodeling through formation of L-ornithine with downstream production of polyamines and L-proline, which are involved in processes of cellular proliferation and collagen deposition. Further research on modulation of arginase activity and L-arginine bioavailability may reveal promising novel therapeutic strategies for asthma. |
format | Online Article Text |
id | pubmed-3124954 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31249542011-07-11 Arginase and Arginine Dysregulation in Asthma Benson, Renée C. Hardy, Karen A. Morris, Claudia R. J Allergy (Cairo) Review Article In recent years, evidence has accumulated indicating that the enzyme arginase, which converts L-arginine into L-ornithine and urea, plays a key role in the pathogenesis of pulmonary disorders such as asthma through dysregulation of L-arginine metabolism and modulation of nitric oxide (NO) homeostasis. Allergic asthma is characterized by airway hyperresponsiveness, inflammation, and remodeling. Through substrate competition, arginase decreases bioavailability of L-arginine for nitric oxide synthase (NOS), thereby limiting NO production with subsequent effects on airway tone and inflammation. By decreasing L-arginine bioavailability, arginase may also contribute to the uncoupling of NOS and the formation of the proinflammatory oxidant peroxynitrite in the airways. Finally, arginase may play a role in the development of chronic airway remodeling through formation of L-ornithine with downstream production of polyamines and L-proline, which are involved in processes of cellular proliferation and collagen deposition. Further research on modulation of arginase activity and L-arginine bioavailability may reveal promising novel therapeutic strategies for asthma. Hindawi Publishing Corporation 2011 2011-04-26 /pmc/articles/PMC3124954/ /pubmed/21747870 http://dx.doi.org/10.1155/2011/736319 Text en Copyright © 2011 Renée C. Benson et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Benson, Renée C. Hardy, Karen A. Morris, Claudia R. Arginase and Arginine Dysregulation in Asthma |
title | Arginase and Arginine Dysregulation in Asthma |
title_full | Arginase and Arginine Dysregulation in Asthma |
title_fullStr | Arginase and Arginine Dysregulation in Asthma |
title_full_unstemmed | Arginase and Arginine Dysregulation in Asthma |
title_short | Arginase and Arginine Dysregulation in Asthma |
title_sort | arginase and arginine dysregulation in asthma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124954/ https://www.ncbi.nlm.nih.gov/pubmed/21747870 http://dx.doi.org/10.1155/2011/736319 |
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