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First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium

Marine pelagic diazotrophic cyanobacteria of the genus Trichodesmium (Oscillatoriales) are widespread throughout the tropics and subtropics, and are particularly common in the waters of New Caledonia. Blooms of Trichodesmium are suspected to be a potential source of toxins in the ciguatera food chai...

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Autores principales: Kerbrat, Anne Sophie, Amzil, Zouher, Pawlowiez, Ralph, Golubic, Stjepko, Sibat, Manoella, Darius, Helene Taiana, Chinain, Mireille, Laurent, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124972/
https://www.ncbi.nlm.nih.gov/pubmed/21731549
http://dx.doi.org/10.3390/md9040543
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author Kerbrat, Anne Sophie
Amzil, Zouher
Pawlowiez, Ralph
Golubic, Stjepko
Sibat, Manoella
Darius, Helene Taiana
Chinain, Mireille
Laurent, Dominique
author_facet Kerbrat, Anne Sophie
Amzil, Zouher
Pawlowiez, Ralph
Golubic, Stjepko
Sibat, Manoella
Darius, Helene Taiana
Chinain, Mireille
Laurent, Dominique
author_sort Kerbrat, Anne Sophie
collection PubMed
description Marine pelagic diazotrophic cyanobacteria of the genus Trichodesmium (Oscillatoriales) are widespread throughout the tropics and subtropics, and are particularly common in the waters of New Caledonia. Blooms of Trichodesmium are suspected to be a potential source of toxins in the ciguatera food chain and were previously reported to contain several types of paralyzing toxins. The toxicity of water-soluble extracts of Trichodesmium spp. were analyzed by mouse bioassay and Neuroblastoma assay and their toxic compounds characterized using liquid chromatography coupled with tandem mass spectrometry techniques. Here, we report the first identification of palytoxin and one of its derivatives, 42-hydroxy-palytoxin, in field samples of Trichodesmium collected in the New Caledonian lagoon. The possible role played by Trichodesmium blooms in the development of clupeotoxism, this human intoxication following the ingestion of plankton-eating fish and classically associated with Ostreopsis blooms, is also discussed.
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spelling pubmed-31249722011-06-30 First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium Kerbrat, Anne Sophie Amzil, Zouher Pawlowiez, Ralph Golubic, Stjepko Sibat, Manoella Darius, Helene Taiana Chinain, Mireille Laurent, Dominique Mar Drugs Article Marine pelagic diazotrophic cyanobacteria of the genus Trichodesmium (Oscillatoriales) are widespread throughout the tropics and subtropics, and are particularly common in the waters of New Caledonia. Blooms of Trichodesmium are suspected to be a potential source of toxins in the ciguatera food chain and were previously reported to contain several types of paralyzing toxins. The toxicity of water-soluble extracts of Trichodesmium spp. were analyzed by mouse bioassay and Neuroblastoma assay and their toxic compounds characterized using liquid chromatography coupled with tandem mass spectrometry techniques. Here, we report the first identification of palytoxin and one of its derivatives, 42-hydroxy-palytoxin, in field samples of Trichodesmium collected in the New Caledonian lagoon. The possible role played by Trichodesmium blooms in the development of clupeotoxism, this human intoxication following the ingestion of plankton-eating fish and classically associated with Ostreopsis blooms, is also discussed. Molecular Diversity Preservation International 2011-03-31 /pmc/articles/PMC3124972/ /pubmed/21731549 http://dx.doi.org/10.3390/md9040543 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kerbrat, Anne Sophie
Amzil, Zouher
Pawlowiez, Ralph
Golubic, Stjepko
Sibat, Manoella
Darius, Helene Taiana
Chinain, Mireille
Laurent, Dominique
First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium
title First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium
title_full First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium
title_fullStr First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium
title_full_unstemmed First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium
title_short First Evidence of Palytoxin and 42-Hydroxy-palytoxin in the Marine Cyanobacterium Trichodesmium
title_sort first evidence of palytoxin and 42-hydroxy-palytoxin in the marine cyanobacterium trichodesmium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124972/
https://www.ncbi.nlm.nih.gov/pubmed/21731549
http://dx.doi.org/10.3390/md9040543
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