Activation of PKR Causes Amyloid ß-Peptide Accumulation via De-Repression of BACE1 Expression

BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively inhibited due to the presence of the 5′untranslated region (5′UTR) in the BACE1 promoter. BACE1 expression is activated by phosphorylation of...

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Detalles Bibliográficos
Autores principales: ILL-Raga, Gerard, Palomer, Ernest, Wozniak, Matthew A., Ramos-Fernández, Eva, Bosch-Morató, Mònica, Tajes, Marta, Guix, Francesc X., Galán, José J., Clarimón, Jordi, Antúnez, Carmen, Real, Luis M., Boada, Mercé, Itzhaki, Ruth F., Fandos, César, Muñoz, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125189/
https://www.ncbi.nlm.nih.gov/pubmed/21738672
http://dx.doi.org/10.1371/journal.pone.0021456

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