Subretinal gene delivery using helper-dependent adenoviral vectors

This study describes the successful delivery of helper-dependent adenoviral vectors to the mouse retina with long term and robust levels of reporter expression in the retina without apparent adverse effects. Since these vectors have a large cloning capacity, they have great potential to extend the s...

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Autores principales: Wu, Linda, Lam, Simon, Cao, Huibi, Guan, Rui, Duan, Rongqi, van der Kooy, Derek, Bremner, Rod, Molday, Robert S, Hu, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125205/
https://www.ncbi.nlm.nih.gov/pubmed/21711866
http://dx.doi.org/10.1186/2045-3701-1-15
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author Wu, Linda
Lam, Simon
Cao, Huibi
Guan, Rui
Duan, Rongqi
van der Kooy, Derek
Bremner, Rod
Molday, Robert S
Hu, Jim
author_facet Wu, Linda
Lam, Simon
Cao, Huibi
Guan, Rui
Duan, Rongqi
van der Kooy, Derek
Bremner, Rod
Molday, Robert S
Hu, Jim
author_sort Wu, Linda
collection PubMed
description This study describes the successful delivery of helper-dependent adenoviral vectors to the mouse retina with long term and robust levels of reporter expression in the retina without apparent adverse effects. Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector.
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spelling pubmed-31252052011-06-29 Subretinal gene delivery using helper-dependent adenoviral vectors Wu, Linda Lam, Simon Cao, Huibi Guan, Rui Duan, Rongqi van der Kooy, Derek Bremner, Rod Molday, Robert S Hu, Jim Cell Biosci Methodology This study describes the successful delivery of helper-dependent adenoviral vectors to the mouse retina with long term and robust levels of reporter expression in the retina without apparent adverse effects. Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector. BioMed Central 2011-04-04 /pmc/articles/PMC3125205/ /pubmed/21711866 http://dx.doi.org/10.1186/2045-3701-1-15 Text en Copyright ©2011 Wu et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Methodology
Wu, Linda
Lam, Simon
Cao, Huibi
Guan, Rui
Duan, Rongqi
van der Kooy, Derek
Bremner, Rod
Molday, Robert S
Hu, Jim
Subretinal gene delivery using helper-dependent adenoviral vectors
title Subretinal gene delivery using helper-dependent adenoviral vectors
title_full Subretinal gene delivery using helper-dependent adenoviral vectors
title_fullStr Subretinal gene delivery using helper-dependent adenoviral vectors
title_full_unstemmed Subretinal gene delivery using helper-dependent adenoviral vectors
title_short Subretinal gene delivery using helper-dependent adenoviral vectors
title_sort subretinal gene delivery using helper-dependent adenoviral vectors
topic Methodology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125205/
https://www.ncbi.nlm.nih.gov/pubmed/21711866
http://dx.doi.org/10.1186/2045-3701-1-15
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