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The effect of cathepsin K deficiency on airway development and TGF-β1 degradation
BACKGROUND: Cathepsin K, a cysteine protease predominantly expressed in osteoclasts, is a major drug target for the treatment of osteoporosis. Recent findings, however, indicate that cathepsin K is also involved in non-skeletal metabolism. The development of fibrotic phenotypes in lung and skin is a...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125223/ https://www.ncbi.nlm.nih.gov/pubmed/21627832 http://dx.doi.org/10.1186/1465-9921-12-72 |