Common variants at 19p13 are associated with susceptibility to ovarian cancer

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world accounting for 4 percent of deaths from cancer in women1. We performed a three-phase genome-wide association study of EOC survival in 8,951 EOC cases with available survival time data,...

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Detalles Bibliográficos
Autores principales: Bolton, Kelly L., Tyrer, Jonathan, Song, Honglin, Ramus, Susan J., Notaridou, Maria, Jones, Chris, Sher, Tanya, Gentry-Maharaj, Aleksandra, Wozniak, Eva, Tsai, Ya-Yu, Weidhaas, Joanne, Paik, Daniel, Van Den Berg, David J., Stram, Daniel O., Pearce, Celeste Leigh, Wu, Anna H., Brewster, Wendy, Anton-Culver, Hoda, Ziogas, Argyrios, Narod, Steven A., Levine, Douglas A., Kaye, Stanley B., Brown, Robert, Paul, Jim, Flanagan, James, Sieh, Weiva, McGuire, Valerie, Whittemore, Alice S., Campbell, Ian, Gore, Martin E., Lissowska, Jolanta, Yang, Hannah, Medrek, Krzysztof, Gronwald, Jacek, Lubinski, Jan, Jakubowska, Anna, Le, Nhu D., Cook, Linda S., Kelemen, Linda E., Brooks-Wilson, Angela, Massuger, Leon F.A.G., Kiemeney, Lambertus A., Aben, Katja K.H., van Altena, Anne M., Houlston, Richard, Tomlinson, Ian, Palmieri, Rachel T., Moorman, Patricia G., Schildkraut, Joellen, Iversen, Edwin S., Phelan, Catherine, Vierkant, Robert A., Cunningham, Julie M., Goode, Ellen L., Fridley, Brooke L., Kruger-Kjaer, Susan, Blaeker, Jan, Hogdall, Estrid, Hogdall, Claus, Gross, Jenny, Karlan, Beth Y., Ness, Roberta B., Edwards, Robert P., Odunsi, Kunle, Moyisch, Kirsten B., Baker, Julie A., Modugno, Francesmary, Heikkinenen, Tuomas, Butzow, Ralf, Nevanlinna, Heli, Leminen, Arto, Bogdanova, Natalia, Antonenkova, Natalia, Doerk, Thilo, Hillemanns, Peter, Dürst, Matthias, Runnebaum, Ingo, Thompson, Pamela J., Carney, Michael E., Goodman, Marc T., Lurie, Galina, Wang-Gohrke, Shan, Hein, Rebecca, Chang-Claude, Jenny, Rossing, Mary Anne, Cushing-Haugen, Kara L., Doherty, Jennifer, Chen, Chu, Rafnar, Thorunn, Besenbacher, Soren, Sulem, Patrick, Stefansson, Kari, Birrer, Michael J., Terry, Kathryn L., Hernandez, Dena, Cramer, Daniel W., Vergote, Ignace, Amant, Frederic, Lambrechts, Diether, Despierre, Evelyn, Fasching, Peter A., Beckmann, Matthias W., Thiel, Falk C., Ekici, Arif B., Chen, Xiaoqing, Johnatty, Sharon E., Webb, Penelope M., Beesley, Jonathan, Chanock, Stephen, Garcia-Closas, Montserrat, Sellers, Tom, Easton, Douglas F., Berchuck, Andrew, Chenevix-Trench, Georgia, Pharoah, Paul D.P., Gayther, Simon A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125495/
https://www.ncbi.nlm.nih.gov/pubmed/20852633
http://dx.doi.org/10.1038/ng.666
Descripción
Sumario:Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world accounting for 4 percent of deaths from cancer in women1. We performed a three-phase genome-wide association study of EOC survival in 8,951 EOC cases with available survival time data, and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P=5×10(−4) and 6×10(−4)), but did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P=3×10(−9) and 4×10(−11) respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1 interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.

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