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Common variants at 19p13 are associated with susceptibility to ovarian cancer
Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world accounting for 4 percent of deaths from cancer in women1. We performed a three-phase genome-wide association study of EOC survival in 8,951 EOC cases with available survival time data,...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125495/ https://www.ncbi.nlm.nih.gov/pubmed/20852633 http://dx.doi.org/10.1038/ng.666 |
| _version_ | 1782207225981304832 |
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| author | Bolton, Kelly L. Tyrer, Jonathan Song, Honglin Ramus, Susan J. Notaridou, Maria Jones, Chris Sher, Tanya Gentry-Maharaj, Aleksandra Wozniak, Eva Tsai, Ya-Yu Weidhaas, Joanne Paik, Daniel Van Den Berg, David J. Stram, Daniel O. Pearce, Celeste Leigh Wu, Anna H. Brewster, Wendy Anton-Culver, Hoda Ziogas, Argyrios Narod, Steven A. Levine, Douglas A. Kaye, Stanley B. Brown, Robert Paul, Jim Flanagan, James Sieh, Weiva McGuire, Valerie Whittemore, Alice S. Campbell, Ian Gore, Martin E. Lissowska, Jolanta Yang, Hannah Medrek, Krzysztof Gronwald, Jacek Lubinski, Jan Jakubowska, Anna Le, Nhu D. Cook, Linda S. Kelemen, Linda E. Brooks-Wilson, Angela Massuger, Leon F.A.G. Kiemeney, Lambertus A. Aben, Katja K.H. van Altena, Anne M. Houlston, Richard Tomlinson, Ian Palmieri, Rachel T. Moorman, Patricia G. Schildkraut, Joellen Iversen, Edwin S. Phelan, Catherine Vierkant, Robert A. Cunningham, Julie M. Goode, Ellen L. Fridley, Brooke L. Kruger-Kjaer, Susan Blaeker, Jan Hogdall, Estrid Hogdall, Claus Gross, Jenny Karlan, Beth Y. Ness, Roberta B. Edwards, Robert P. Odunsi, Kunle Moyisch, Kirsten B. Baker, Julie A. Modugno, Francesmary Heikkinenen, Tuomas Butzow, Ralf Nevanlinna, Heli Leminen, Arto Bogdanova, Natalia Antonenkova, Natalia Doerk, Thilo Hillemanns, Peter Dürst, Matthias Runnebaum, Ingo Thompson, Pamela J. Carney, Michael E. Goodman, Marc T. Lurie, Galina Wang-Gohrke, Shan Hein, Rebecca Chang-Claude, Jenny Rossing, Mary Anne Cushing-Haugen, Kara L. Doherty, Jennifer Chen, Chu Rafnar, Thorunn Besenbacher, Soren Sulem, Patrick Stefansson, Kari Birrer, Michael J. Terry, Kathryn L. Hernandez, Dena Cramer, Daniel W. Vergote, Ignace Amant, Frederic Lambrechts, Diether Despierre, Evelyn Fasching, Peter A. Beckmann, Matthias W. Thiel, Falk C. Ekici, Arif B. Chen, Xiaoqing Johnatty, Sharon E. Webb, Penelope M. Beesley, Jonathan Chanock, Stephen Garcia-Closas, Montserrat Sellers, Tom Easton, Douglas F. Berchuck, Andrew Chenevix-Trench, Georgia Pharoah, Paul D.P. Gayther, Simon A. |
| author_facet | Bolton, Kelly L. Tyrer, Jonathan Song, Honglin Ramus, Susan J. Notaridou, Maria Jones, Chris Sher, Tanya Gentry-Maharaj, Aleksandra Wozniak, Eva Tsai, Ya-Yu Weidhaas, Joanne Paik, Daniel Van Den Berg, David J. Stram, Daniel O. Pearce, Celeste Leigh Wu, Anna H. Brewster, Wendy Anton-Culver, Hoda Ziogas, Argyrios Narod, Steven A. Levine, Douglas A. Kaye, Stanley B. Brown, Robert Paul, Jim Flanagan, James Sieh, Weiva McGuire, Valerie Whittemore, Alice S. Campbell, Ian Gore, Martin E. Lissowska, Jolanta Yang, Hannah Medrek, Krzysztof Gronwald, Jacek Lubinski, Jan Jakubowska, Anna Le, Nhu D. Cook, Linda S. Kelemen, Linda E. Brooks-Wilson, Angela Massuger, Leon F.A.G. Kiemeney, Lambertus A. Aben, Katja K.H. van Altena, Anne M. Houlston, Richard Tomlinson, Ian Palmieri, Rachel T. Moorman, Patricia G. Schildkraut, Joellen Iversen, Edwin S. Phelan, Catherine Vierkant, Robert A. Cunningham, Julie M. Goode, Ellen L. Fridley, Brooke L. Kruger-Kjaer, Susan Blaeker, Jan Hogdall, Estrid Hogdall, Claus Gross, Jenny Karlan, Beth Y. Ness, Roberta B. Edwards, Robert P. Odunsi, Kunle Moyisch, Kirsten B. Baker, Julie A. Modugno, Francesmary Heikkinenen, Tuomas Butzow, Ralf Nevanlinna, Heli Leminen, Arto Bogdanova, Natalia Antonenkova, Natalia Doerk, Thilo Hillemanns, Peter Dürst, Matthias Runnebaum, Ingo Thompson, Pamela J. Carney, Michael E. Goodman, Marc T. Lurie, Galina Wang-Gohrke, Shan Hein, Rebecca Chang-Claude, Jenny Rossing, Mary Anne Cushing-Haugen, Kara L. Doherty, Jennifer Chen, Chu Rafnar, Thorunn Besenbacher, Soren Sulem, Patrick Stefansson, Kari Birrer, Michael J. Terry, Kathryn L. Hernandez, Dena Cramer, Daniel W. Vergote, Ignace Amant, Frederic Lambrechts, Diether Despierre, Evelyn Fasching, Peter A. Beckmann, Matthias W. Thiel, Falk C. Ekici, Arif B. Chen, Xiaoqing Johnatty, Sharon E. Webb, Penelope M. Beesley, Jonathan Chanock, Stephen Garcia-Closas, Montserrat Sellers, Tom Easton, Douglas F. Berchuck, Andrew Chenevix-Trench, Georgia Pharoah, Paul D.P. Gayther, Simon A. |
| author_sort | Bolton, Kelly L. |
| collection | PubMed |
| description | Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world accounting for 4 percent of deaths from cancer in women1. We performed a three-phase genome-wide association study of EOC survival in 8,951 EOC cases with available survival time data, and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P=5×10(−4) and 6×10(−4)), but did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P=3×10(−9) and 4×10(−11) respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1 interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development. |
| format | Online Article Text |
| id | pubmed-3125495 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-31254952011-06-29 Common variants at 19p13 are associated with susceptibility to ovarian cancer Bolton, Kelly L. Tyrer, Jonathan Song, Honglin Ramus, Susan J. Notaridou, Maria Jones, Chris Sher, Tanya Gentry-Maharaj, Aleksandra Wozniak, Eva Tsai, Ya-Yu Weidhaas, Joanne Paik, Daniel Van Den Berg, David J. Stram, Daniel O. Pearce, Celeste Leigh Wu, Anna H. Brewster, Wendy Anton-Culver, Hoda Ziogas, Argyrios Narod, Steven A. Levine, Douglas A. Kaye, Stanley B. Brown, Robert Paul, Jim Flanagan, James Sieh, Weiva McGuire, Valerie Whittemore, Alice S. Campbell, Ian Gore, Martin E. Lissowska, Jolanta Yang, Hannah Medrek, Krzysztof Gronwald, Jacek Lubinski, Jan Jakubowska, Anna Le, Nhu D. Cook, Linda S. Kelemen, Linda E. Brooks-Wilson, Angela Massuger, Leon F.A.G. Kiemeney, Lambertus A. Aben, Katja K.H. van Altena, Anne M. Houlston, Richard Tomlinson, Ian Palmieri, Rachel T. Moorman, Patricia G. Schildkraut, Joellen Iversen, Edwin S. Phelan, Catherine Vierkant, Robert A. Cunningham, Julie M. Goode, Ellen L. Fridley, Brooke L. Kruger-Kjaer, Susan Blaeker, Jan Hogdall, Estrid Hogdall, Claus Gross, Jenny Karlan, Beth Y. Ness, Roberta B. Edwards, Robert P. Odunsi, Kunle Moyisch, Kirsten B. Baker, Julie A. Modugno, Francesmary Heikkinenen, Tuomas Butzow, Ralf Nevanlinna, Heli Leminen, Arto Bogdanova, Natalia Antonenkova, Natalia Doerk, Thilo Hillemanns, Peter Dürst, Matthias Runnebaum, Ingo Thompson, Pamela J. Carney, Michael E. Goodman, Marc T. Lurie, Galina Wang-Gohrke, Shan Hein, Rebecca Chang-Claude, Jenny Rossing, Mary Anne Cushing-Haugen, Kara L. Doherty, Jennifer Chen, Chu Rafnar, Thorunn Besenbacher, Soren Sulem, Patrick Stefansson, Kari Birrer, Michael J. Terry, Kathryn L. Hernandez, Dena Cramer, Daniel W. Vergote, Ignace Amant, Frederic Lambrechts, Diether Despierre, Evelyn Fasching, Peter A. Beckmann, Matthias W. Thiel, Falk C. Ekici, Arif B. Chen, Xiaoqing Johnatty, Sharon E. Webb, Penelope M. Beesley, Jonathan Chanock, Stephen Garcia-Closas, Montserrat Sellers, Tom Easton, Douglas F. Berchuck, Andrew Chenevix-Trench, Georgia Pharoah, Paul D.P. Gayther, Simon A. Nat Genet Article Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world accounting for 4 percent of deaths from cancer in women1. We performed a three-phase genome-wide association study of EOC survival in 8,951 EOC cases with available survival time data, and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P=5×10(−4) and 6×10(−4)), but did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P=3×10(−9) and 4×10(−11) respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1 interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development. 2010-09-19 2010-10 /pmc/articles/PMC3125495/ /pubmed/20852633 http://dx.doi.org/10.1038/ng.666 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Bolton, Kelly L. Tyrer, Jonathan Song, Honglin Ramus, Susan J. Notaridou, Maria Jones, Chris Sher, Tanya Gentry-Maharaj, Aleksandra Wozniak, Eva Tsai, Ya-Yu Weidhaas, Joanne Paik, Daniel Van Den Berg, David J. Stram, Daniel O. Pearce, Celeste Leigh Wu, Anna H. Brewster, Wendy Anton-Culver, Hoda Ziogas, Argyrios Narod, Steven A. Levine, Douglas A. Kaye, Stanley B. Brown, Robert Paul, Jim Flanagan, James Sieh, Weiva McGuire, Valerie Whittemore, Alice S. Campbell, Ian Gore, Martin E. Lissowska, Jolanta Yang, Hannah Medrek, Krzysztof Gronwald, Jacek Lubinski, Jan Jakubowska, Anna Le, Nhu D. Cook, Linda S. Kelemen, Linda E. Brooks-Wilson, Angela Massuger, Leon F.A.G. Kiemeney, Lambertus A. Aben, Katja K.H. van Altena, Anne M. Houlston, Richard Tomlinson, Ian Palmieri, Rachel T. Moorman, Patricia G. Schildkraut, Joellen Iversen, Edwin S. Phelan, Catherine Vierkant, Robert A. Cunningham, Julie M. Goode, Ellen L. Fridley, Brooke L. Kruger-Kjaer, Susan Blaeker, Jan Hogdall, Estrid Hogdall, Claus Gross, Jenny Karlan, Beth Y. Ness, Roberta B. Edwards, Robert P. Odunsi, Kunle Moyisch, Kirsten B. Baker, Julie A. Modugno, Francesmary Heikkinenen, Tuomas Butzow, Ralf Nevanlinna, Heli Leminen, Arto Bogdanova, Natalia Antonenkova, Natalia Doerk, Thilo Hillemanns, Peter Dürst, Matthias Runnebaum, Ingo Thompson, Pamela J. Carney, Michael E. Goodman, Marc T. Lurie, Galina Wang-Gohrke, Shan Hein, Rebecca Chang-Claude, Jenny Rossing, Mary Anne Cushing-Haugen, Kara L. Doherty, Jennifer Chen, Chu Rafnar, Thorunn Besenbacher, Soren Sulem, Patrick Stefansson, Kari Birrer, Michael J. Terry, Kathryn L. Hernandez, Dena Cramer, Daniel W. Vergote, Ignace Amant, Frederic Lambrechts, Diether Despierre, Evelyn Fasching, Peter A. Beckmann, Matthias W. Thiel, Falk C. Ekici, Arif B. Chen, Xiaoqing Johnatty, Sharon E. Webb, Penelope M. Beesley, Jonathan Chanock, Stephen Garcia-Closas, Montserrat Sellers, Tom Easton, Douglas F. Berchuck, Andrew Chenevix-Trench, Georgia Pharoah, Paul D.P. Gayther, Simon A. Common variants at 19p13 are associated with susceptibility to ovarian cancer |
| title | Common variants at 19p13 are associated with susceptibility to ovarian cancer |
| title_full | Common variants at 19p13 are associated with susceptibility to ovarian cancer |
| title_fullStr | Common variants at 19p13 are associated with susceptibility to ovarian cancer |
| title_full_unstemmed | Common variants at 19p13 are associated with susceptibility to ovarian cancer |
| title_short | Common variants at 19p13 are associated with susceptibility to ovarian cancer |
| title_sort | common variants at 19p13 are associated with susceptibility to ovarian cancer |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125495/ https://www.ncbi.nlm.nih.gov/pubmed/20852633 http://dx.doi.org/10.1038/ng.666 |
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