Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases

Nevirapine is a non-nucleoside reverse transcriptase inhibitor, widely used in combination with other antiretroviral agents for treatment of HIV infection. Steven Johnson syndrome (SJS) is the major toxicity of nevirapine. We describe here four cases of SJS in HIV seropositive patients following nev...

Descripción completa

Detalles Bibliográficos
Autores principales: Balasundaram, S, Ranganathan, K, Umadevi, K, Gunaseelan, R, Kumaraswamy, N, Solomon, Sunithi, Devaleenol, Bella, Ambrose, Pradeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125654/
https://www.ncbi.nlm.nih.gov/pubmed/21731276
http://dx.doi.org/10.4103/0973-029X.80024
_version_ 1782207238160515072
author Balasundaram, S
Ranganathan, K
Umadevi, K
Gunaseelan, R
Kumaraswamy, N
Solomon, Sunithi
Devaleenol, Bella
Ambrose, Pradeep
author_facet Balasundaram, S
Ranganathan, K
Umadevi, K
Gunaseelan, R
Kumaraswamy, N
Solomon, Sunithi
Devaleenol, Bella
Ambrose, Pradeep
author_sort Balasundaram, S
collection PubMed
description Nevirapine is a non-nucleoside reverse transcriptase inhibitor, widely used in combination with other antiretroviral agents for treatment of HIV infection. Steven Johnson syndrome (SJS) is the major toxicity of nevirapine. We describe here four cases of SJS in HIV seropositive patients following nevirapine therapy. In all four cases cutaneous hypersensitivity reaction was seen with extreme oral lesions, three patients presented clinically with elevated liver enzymes and hepatitis, and two patients had ocular involvement.
format Online
Article
Text
id pubmed-3125654
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-31256542011-07-01 Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases Balasundaram, S Ranganathan, K Umadevi, K Gunaseelan, R Kumaraswamy, N Solomon, Sunithi Devaleenol, Bella Ambrose, Pradeep J Oral Maxillofac Pathol Case Report Nevirapine is a non-nucleoside reverse transcriptase inhibitor, widely used in combination with other antiretroviral agents for treatment of HIV infection. Steven Johnson syndrome (SJS) is the major toxicity of nevirapine. We describe here four cases of SJS in HIV seropositive patients following nevirapine therapy. In all four cases cutaneous hypersensitivity reaction was seen with extreme oral lesions, three patients presented clinically with elevated liver enzymes and hepatitis, and two patients had ocular involvement. Medknow Publications 2011 /pmc/articles/PMC3125654/ /pubmed/21731276 http://dx.doi.org/10.4103/0973-029X.80024 Text en © Journal of Oral and Maxillofacial Pathology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Balasundaram, S
Ranganathan, K
Umadevi, K
Gunaseelan, R
Kumaraswamy, N
Solomon, Sunithi
Devaleenol, Bella
Ambrose, Pradeep
Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases
title Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases
title_full Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases
title_fullStr Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases
title_full_unstemmed Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases
title_short Oral lesions associated with nevirapine-related Stevens Johnson syndrome: A report of four cases
title_sort oral lesions associated with nevirapine-related stevens johnson syndrome: a report of four cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125654/
https://www.ncbi.nlm.nih.gov/pubmed/21731276
http://dx.doi.org/10.4103/0973-029X.80024
work_keys_str_mv AT balasundarams orallesionsassociatedwithnevirapinerelatedstevensjohnsonsyndromeareportoffourcases
AT ranganathank orallesionsassociatedwithnevirapinerelatedstevensjohnsonsyndromeareportoffourcases
AT umadevik orallesionsassociatedwithnevirapinerelatedstevensjohnsonsyndromeareportoffourcases
AT gunaseelanr orallesionsassociatedwithnevirapinerelatedstevensjohnsonsyndromeareportoffourcases
AT kumaraswamyn orallesionsassociatedwithnevirapinerelatedstevensjohnsonsyndromeareportoffourcases
AT solomonsunithi orallesionsassociatedwithnevirapinerelatedstevensjohnsonsyndromeareportoffourcases
AT devaleenolbella orallesionsassociatedwithnevirapinerelatedstevensjohnsonsyndromeareportoffourcases
AT ambrosepradeep orallesionsassociatedwithnevirapinerelatedstevensjohnsonsyndromeareportoffourcases

Ejemplares similares