mirAct: a web tool for evaluating microRNA activity based on gene expression data

MicroRNAs (miRNAs) are critical regulators in the complex cellular networks. The mirAct web server (http://sysbio.ustc.edu.cn/software/mirAct) is a tool designed to investigate miRNA activity based on gene-expression data by using the negative regulation relationship between miRNAs and their target...

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Detalles Bibliográficos
Autores principales: Liang, Zhi, Zhou, Hong, He, Zongxiao, Zheng, Haoran, Wu, Jiarui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125759/
https://www.ncbi.nlm.nih.gov/pubmed/21596785
http://dx.doi.org/10.1093/nar/gkr351
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author Liang, Zhi
Zhou, Hong
He, Zongxiao
Zheng, Haoran
Wu, Jiarui
author_facet Liang, Zhi
Zhou, Hong
He, Zongxiao
Zheng, Haoran
Wu, Jiarui
author_sort Liang, Zhi
collection PubMed
description MicroRNAs (miRNAs) are critical regulators in the complex cellular networks. The mirAct web server (http://sysbio.ustc.edu.cn/software/mirAct) is a tool designed to investigate miRNA activity based on gene-expression data by using the negative regulation relationship between miRNAs and their target genes. mirAct supports multiple-class data and enables clustering analysis based on computationally determined miRNA activity. Here, we describe the framework of mirAct, demonstrate its performance by comparing with other similar programs and exemplify its applications using case studies.
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spelling pubmed-31257592011-07-05 mirAct: a web tool for evaluating microRNA activity based on gene expression data Liang, Zhi Zhou, Hong He, Zongxiao Zheng, Haoran Wu, Jiarui Nucleic Acids Res Articles MicroRNAs (miRNAs) are critical regulators in the complex cellular networks. The mirAct web server (http://sysbio.ustc.edu.cn/software/mirAct) is a tool designed to investigate miRNA activity based on gene-expression data by using the negative regulation relationship between miRNAs and their target genes. mirAct supports multiple-class data and enables clustering analysis based on computationally determined miRNA activity. Here, we describe the framework of mirAct, demonstrate its performance by comparing with other similar programs and exemplify its applications using case studies. Oxford University Press 2011-07-01 2011-05-19 /pmc/articles/PMC3125759/ /pubmed/21596785 http://dx.doi.org/10.1093/nar/gkr351 Text en © The Author(s) 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Liang, Zhi
Zhou, Hong
He, Zongxiao
Zheng, Haoran
Wu, Jiarui
mirAct: a web tool for evaluating microRNA activity based on gene expression data
title mirAct: a web tool for evaluating microRNA activity based on gene expression data
title_full mirAct: a web tool for evaluating microRNA activity based on gene expression data
title_fullStr mirAct: a web tool for evaluating microRNA activity based on gene expression data
title_full_unstemmed mirAct: a web tool for evaluating microRNA activity based on gene expression data
title_short mirAct: a web tool for evaluating microRNA activity based on gene expression data
title_sort miract: a web tool for evaluating microrna activity based on gene expression data
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125759/
https://www.ncbi.nlm.nih.gov/pubmed/21596785
http://dx.doi.org/10.1093/nar/gkr351
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AT zhenghaoran miractawebtoolforevaluatingmicrornaactivitybasedongeneexpressiondata
AT wujiarui miractawebtoolforevaluatingmicrornaactivitybasedongeneexpressiondata

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