A Directed Molecular Evolution Approach to Improved Immunogenicity of the HIV-1 Envelope Glycoprotein

A prophylactic vaccine is needed to slow the spread of HIV-1 infection. Optimization of the wild-type envelope glycoproteins to create immunogens that can elicit effective neutralizing antibodies is a high priority. Starting with ten genes encoding subtype B HIV-1 gp120 envelope glycoproteins and us...

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Detalles Bibliográficos
Autores principales: Du, Sean X., Xu, Li, Zhang, Wenge, Tang, Susan, Boenig, Rebecca I., Chen, Helen, Mariano, Ellaine B., Zwick, Michael B., Parren, Paul W. H. I., Burton, Dennis R., Wrin, Terri, Petropoulos, Christos J., Ballantyne, John A., Chambers, Michael, Whalen, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126809/
https://www.ncbi.nlm.nih.gov/pubmed/21738594
http://dx.doi.org/10.1371/journal.pone.0020927

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