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Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi

Endopleura uchi is a typical Amazonian tree and its bark is popularly employed in the preparation of teas against myomas, arthritis, influenza, diarrhea and cancer. In this study, the antioxidant activity, cytotoxicity and antimicrobial activity of five different extracts of the bark, selected by th...

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Autores principales: Politi, Flávio A. S., de Mello, João C. P., Migliato, Ketylin F., Nepomuceno, Andréa L. A., Moreira, Raquel R. D., Pietro, Rosemeire C. L. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127145/
https://www.ncbi.nlm.nih.gov/pubmed/21731469
http://dx.doi.org/10.3390/ijms12042757
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author Politi, Flávio A. S.
de Mello, João C. P.
Migliato, Ketylin F.
Nepomuceno, Andréa L. A.
Moreira, Raquel R. D.
Pietro, Rosemeire C. L. R.
author_facet Politi, Flávio A. S.
de Mello, João C. P.
Migliato, Ketylin F.
Nepomuceno, Andréa L. A.
Moreira, Raquel R. D.
Pietro, Rosemeire C. L. R.
author_sort Politi, Flávio A. S.
collection PubMed
description Endopleura uchi is a typical Amazonian tree and its bark is popularly employed in the preparation of teas against myomas, arthritis, influenza, diarrhea and cancer. In this study, the antioxidant activity, cytotoxicity and antimicrobial activity of five different extracts of the bark, selected by their total tannin content, were assessed. The potential antioxidant activity of the extracts was determined by 2.2-diphenyl-1-picrylhydrazyl radical scavenging assay and the values found were very similar among the extracts and to the standards antioxidants used in the tests. Cytotoxicity analysis in mammalian cells indicated that all the tested extracts exhibited IC(50) values higher than the highest concentration used, showing that they do not present a risk when consumed under these conditions. Extract tested against five bacterial strains and one yeast strain did not show satisfactory growth inhibitory activity, and even the extracts that showed some antimicrobial activity were not effective at any dilution to determine the minimum inhibitory concentration. The results may serve as a reference for subsequent works, since such reference values described in the literature for the bark of E. uchi.
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spelling pubmed-31271452011-06-30 Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi Politi, Flávio A. S. de Mello, João C. P. Migliato, Ketylin F. Nepomuceno, Andréa L. A. Moreira, Raquel R. D. Pietro, Rosemeire C. L. R. Int J Mol Sci Article Endopleura uchi is a typical Amazonian tree and its bark is popularly employed in the preparation of teas against myomas, arthritis, influenza, diarrhea and cancer. In this study, the antioxidant activity, cytotoxicity and antimicrobial activity of five different extracts of the bark, selected by their total tannin content, were assessed. The potential antioxidant activity of the extracts was determined by 2.2-diphenyl-1-picrylhydrazyl radical scavenging assay and the values found were very similar among the extracts and to the standards antioxidants used in the tests. Cytotoxicity analysis in mammalian cells indicated that all the tested extracts exhibited IC(50) values higher than the highest concentration used, showing that they do not present a risk when consumed under these conditions. Extract tested against five bacterial strains and one yeast strain did not show satisfactory growth inhibitory activity, and even the extracts that showed some antimicrobial activity were not effective at any dilution to determine the minimum inhibitory concentration. The results may serve as a reference for subsequent works, since such reference values described in the literature for the bark of E. uchi. Molecular Diversity Preservation International (MDPI) 2011-04-21 /pmc/articles/PMC3127145/ /pubmed/21731469 http://dx.doi.org/10.3390/ijms12042757 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Politi, Flávio A. S.
de Mello, João C. P.
Migliato, Ketylin F.
Nepomuceno, Andréa L. A.
Moreira, Raquel R. D.
Pietro, Rosemeire C. L. R.
Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi
title Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi
title_full Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi
title_fullStr Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi
title_full_unstemmed Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi
title_short Antimicrobial, Cytotoxic and Antioxidant Activities and Determination of the Total Tannin Content of Bark Extracts Endopleura uchi
title_sort antimicrobial, cytotoxic and antioxidant activities and determination of the total tannin content of bark extracts endopleura uchi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127145/
https://www.ncbi.nlm.nih.gov/pubmed/21731469
http://dx.doi.org/10.3390/ijms12042757
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