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The impact of acute organ dysfunction on patients' mortality with severe sepsis

BACKGROUND: Severe sepsis leads to organ failure and results in high mortality. Organ dysfunction is an independent prognostic factor for intensive care unit (ICU) mortality. The objective of the present study was to determine the effect of acute organ dysfunction for ICU mortality in patients with...

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Autores principales: Umegaki, Takeshi, Ikai, Hiroshi, Imanaka, Yuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications Pvt Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127295/
https://www.ncbi.nlm.nih.gov/pubmed/21772676
http://dx.doi.org/10.4103/0970-9185.81816
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author Umegaki, Takeshi
Ikai, Hiroshi
Imanaka, Yuichi
author_facet Umegaki, Takeshi
Ikai, Hiroshi
Imanaka, Yuichi
author_sort Umegaki, Takeshi
collection PubMed
description BACKGROUND: Severe sepsis leads to organ failure and results in high mortality. Organ dysfunction is an independent prognostic factor for intensive care unit (ICU) mortality. The objective of the present study was to determine the effect of acute organ dysfunction for ICU mortality in patients with severe sepsis using administrative data. MATERIALS AND METHODS: A multicenter cross-sectional study was performed in 2008. The study was conducted in 112 teaching hospitals in Japan. All cases with severe sepsis in ICU were identified from administrative data. RESULTS: Administrative data acquired for 4196 severe septic cases of 75,069 cases entered in the ICU were used to assess patient outcomes. Cardiovascular dysfunction was identified as the most major organ dysfunction (73.0%), and the followings were respiratory dysfunction (69.4%) and renal dysfunction (39.0%), respectively. The ICU mortality and 28-day means 28-day from ICU entry. were 18.8% and 27.7%, respectively. After adjustment for age, gender, and severity of illness, the hazard ratio of 2, 3, and ≥4, the organ dysfunctions for one organ failure on ICU mortality was 1.6, 2.0, and 2.7, respectively. CONCLUSIONS: We showed that the number of organ dysfunction was a useful indicator for ICU mortality on administrative data. The hepatic dysfunction was the highest mortality among organ dysfunctions. The hazard ratio of ICU death in severe septic patients with multiple organ dysfunctions was average 2.2 times higher than severe septic patients with single organ dysfunction.
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spelling pubmed-31272952011-07-19 The impact of acute organ dysfunction on patients' mortality with severe sepsis Umegaki, Takeshi Ikai, Hiroshi Imanaka, Yuichi J Anaesthesiol Clin Pharmacol Original Article BACKGROUND: Severe sepsis leads to organ failure and results in high mortality. Organ dysfunction is an independent prognostic factor for intensive care unit (ICU) mortality. The objective of the present study was to determine the effect of acute organ dysfunction for ICU mortality in patients with severe sepsis using administrative data. MATERIALS AND METHODS: A multicenter cross-sectional study was performed in 2008. The study was conducted in 112 teaching hospitals in Japan. All cases with severe sepsis in ICU were identified from administrative data. RESULTS: Administrative data acquired for 4196 severe septic cases of 75,069 cases entered in the ICU were used to assess patient outcomes. Cardiovascular dysfunction was identified as the most major organ dysfunction (73.0%), and the followings were respiratory dysfunction (69.4%) and renal dysfunction (39.0%), respectively. The ICU mortality and 28-day means 28-day from ICU entry. were 18.8% and 27.7%, respectively. After adjustment for age, gender, and severity of illness, the hazard ratio of 2, 3, and ≥4, the organ dysfunctions for one organ failure on ICU mortality was 1.6, 2.0, and 2.7, respectively. CONCLUSIONS: We showed that the number of organ dysfunction was a useful indicator for ICU mortality on administrative data. The hepatic dysfunction was the highest mortality among organ dysfunctions. The hazard ratio of ICU death in severe septic patients with multiple organ dysfunctions was average 2.2 times higher than severe septic patients with single organ dysfunction. Medknow Publications Pvt Ltd 2011 /pmc/articles/PMC3127295/ /pubmed/21772676 http://dx.doi.org/10.4103/0970-9185.81816 Text en © Journal of Anaesthesiology Clinical Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Umegaki, Takeshi
Ikai, Hiroshi
Imanaka, Yuichi
The impact of acute organ dysfunction on patients' mortality with severe sepsis
title The impact of acute organ dysfunction on patients' mortality with severe sepsis
title_full The impact of acute organ dysfunction on patients' mortality with severe sepsis
title_fullStr The impact of acute organ dysfunction on patients' mortality with severe sepsis
title_full_unstemmed The impact of acute organ dysfunction on patients' mortality with severe sepsis
title_short The impact of acute organ dysfunction on patients' mortality with severe sepsis
title_sort impact of acute organ dysfunction on patients' mortality with severe sepsis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127295/
https://www.ncbi.nlm.nih.gov/pubmed/21772676
http://dx.doi.org/10.4103/0970-9185.81816
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