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Is Network Clustering Detectable in Transmission Trees?

Networks are often used to model the contact processes that allow pathogens to spread between hosts but it remains unclear which models best describe these networks. One question is whether clustering in networks, roughly defined as the propensity for triangles to form, affects the dynamics of disea...

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Detalles Bibliográficos
Autor principal: Welch, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127449/
https://www.ncbi.nlm.nih.gov/pubmed/21731813
http://dx.doi.org/10.3390/v3060659
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author Welch, David
author_facet Welch, David
author_sort Welch, David
collection PubMed
description Networks are often used to model the contact processes that allow pathogens to spread between hosts but it remains unclear which models best describe these networks. One question is whether clustering in networks, roughly defined as the propensity for triangles to form, affects the dynamics of disease spread. We perform a simulation study to see if there is a signal in epidemic transmission trees of clustering. We simulate susceptible-exposed-infectious-removed (SEIR) epidemics (with no re-infection) over networks with fixed degree sequences but different levels of clustering and compare trees from networks with the same degree sequence and different clustering levels. We find that the variation of such trees simulated on networks with different levels of clustering is barely greater than those simulated on networks with the same level of clustering, suggesting that clustering can not be detected in transmission data when re-infection does not occur.
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spelling pubmed-31274492011-06-30 Is Network Clustering Detectable in Transmission Trees? Welch, David Viruses Article Networks are often used to model the contact processes that allow pathogens to spread between hosts but it remains unclear which models best describe these networks. One question is whether clustering in networks, roughly defined as the propensity for triangles to form, affects the dynamics of disease spread. We perform a simulation study to see if there is a signal in epidemic transmission trees of clustering. We simulate susceptible-exposed-infectious-removed (SEIR) epidemics (with no re-infection) over networks with fixed degree sequences but different levels of clustering and compare trees from networks with the same degree sequence and different clustering levels. We find that the variation of such trees simulated on networks with different levels of clustering is barely greater than those simulated on networks with the same level of clustering, suggesting that clustering can not be detected in transmission data when re-infection does not occur. Molecular Diversity Preservation International (MDPI) 2011-06-03 /pmc/articles/PMC3127449/ /pubmed/21731813 http://dx.doi.org/10.3390/v3060659 Text en © 2011 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/.)
spellingShingle Article
Welch, David
Is Network Clustering Detectable in Transmission Trees?
title Is Network Clustering Detectable in Transmission Trees?
title_full Is Network Clustering Detectable in Transmission Trees?
title_fullStr Is Network Clustering Detectable in Transmission Trees?
title_full_unstemmed Is Network Clustering Detectable in Transmission Trees?
title_short Is Network Clustering Detectable in Transmission Trees?
title_sort is network clustering detectable in transmission trees?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127449/
https://www.ncbi.nlm.nih.gov/pubmed/21731813
http://dx.doi.org/10.3390/v3060659
work_keys_str_mv AT welchdavid isnetworkclusteringdetectableintransmissiontrees