Endoplasmic Reticulum Stress-Induced JNK Activation Is a Critical Event Leading to Mitochondria-Mediated Cell Death Caused by β-Lapachone Treatment

BACKGROUND: β-lapachone (β-lap) is a bioreductive agent that is activated by the two-electron reductase NAD(P)H quinone oxidoreductase 1 (NQO1). Although β-lap has been reported to induce apoptosis in various cancer types in an NQO1-dependent manner, the signaling pathways by which β-lap causes apop...

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Detalles Bibliográficos
Autores principales: Lee, Hyemi, Park, Moon-Taek, Choi, Bo-Hwa, Oh, Eun-Taex, Song, Min-Jeong, Lee, Jeonghun, Kim, Chulhee, Lim, Byung Uk, Park, Heon Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127577/
https://www.ncbi.nlm.nih.gov/pubmed/21738692
http://dx.doi.org/10.1371/journal.pone.0021533

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