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Evidence for a heritable predisposition to Chronic Fatigue Syndrome

BACKGROUND: Chronic Fatigue Syndrome (CFS) came to attention in the 1980s, but initial investigations did not find organic causes. Now decades later, the etiology of CFS has yet to be understood, and the role of genetic predisposition in CFS remains controversial. Recent reports of CFS association w...

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Autores principales: Albright, Frederick, Light, Kathleen, Light, Alan, Bateman, Lucinda, Cannon-Albright, Lisa A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128000/
https://www.ncbi.nlm.nih.gov/pubmed/21619629
http://dx.doi.org/10.1186/1471-2377-11-62
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author Albright, Frederick
Light, Kathleen
Light, Alan
Bateman, Lucinda
Cannon-Albright, Lisa A
author_facet Albright, Frederick
Light, Kathleen
Light, Alan
Bateman, Lucinda
Cannon-Albright, Lisa A
author_sort Albright, Frederick
collection PubMed
description BACKGROUND: Chronic Fatigue Syndrome (CFS) came to attention in the 1980s, but initial investigations did not find organic causes. Now decades later, the etiology of CFS has yet to be understood, and the role of genetic predisposition in CFS remains controversial. Recent reports of CFS association with the retrovirus xenotropic murine leukemic virus-related virus (XMRV) or other murine leukemia related retroviruses (MLV) might also suggest underlying genetic implications within the host immune system. METHODS: We present analyses of familial clustering of CFS in a computerized genealogical resource linking multiple generations of genealogy data with medical diagnosis data of a large Utah health care system. We compare pair-wise relatedness among cases to expected relatedness in the Utah population, and we estimate risk for CFS for first, second, and third degree relatives of CFS cases. RESULTS: We observed significant excess relatedness of CFS cases compared to that expected in this population. Significant excess relatedness was observed for both close (p <0.001) and distant relationships (p = 0.010). We also observed significant excess CFS relative risk among first (2.70, 95% CI: 1.56-4.66), second (2.34, 95% CI: 1.31-4.19), and third degree relatives (1.93, 95% CI: 1.21-3.07). CONCLUSIONS: These analyses provide strong support for a heritable contribution to predisposition to Chronic Fatigue Syndrome. A population of high-risk CFS pedigrees has been identified, the study of which may provide additional understanding.
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spelling pubmed-31280002011-07-01 Evidence for a heritable predisposition to Chronic Fatigue Syndrome Albright, Frederick Light, Kathleen Light, Alan Bateman, Lucinda Cannon-Albright, Lisa A BMC Neurol Research Article BACKGROUND: Chronic Fatigue Syndrome (CFS) came to attention in the 1980s, but initial investigations did not find organic causes. Now decades later, the etiology of CFS has yet to be understood, and the role of genetic predisposition in CFS remains controversial. Recent reports of CFS association with the retrovirus xenotropic murine leukemic virus-related virus (XMRV) or other murine leukemia related retroviruses (MLV) might also suggest underlying genetic implications within the host immune system. METHODS: We present analyses of familial clustering of CFS in a computerized genealogical resource linking multiple generations of genealogy data with medical diagnosis data of a large Utah health care system. We compare pair-wise relatedness among cases to expected relatedness in the Utah population, and we estimate risk for CFS for first, second, and third degree relatives of CFS cases. RESULTS: We observed significant excess relatedness of CFS cases compared to that expected in this population. Significant excess relatedness was observed for both close (p <0.001) and distant relationships (p = 0.010). We also observed significant excess CFS relative risk among first (2.70, 95% CI: 1.56-4.66), second (2.34, 95% CI: 1.31-4.19), and third degree relatives (1.93, 95% CI: 1.21-3.07). CONCLUSIONS: These analyses provide strong support for a heritable contribution to predisposition to Chronic Fatigue Syndrome. A population of high-risk CFS pedigrees has been identified, the study of which may provide additional understanding. BioMed Central 2011-05-27 /pmc/articles/PMC3128000/ /pubmed/21619629 http://dx.doi.org/10.1186/1471-2377-11-62 Text en Copyright ©2011 Albright et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Albright, Frederick
Light, Kathleen
Light, Alan
Bateman, Lucinda
Cannon-Albright, Lisa A
Evidence for a heritable predisposition to Chronic Fatigue Syndrome
title Evidence for a heritable predisposition to Chronic Fatigue Syndrome
title_full Evidence for a heritable predisposition to Chronic Fatigue Syndrome
title_fullStr Evidence for a heritable predisposition to Chronic Fatigue Syndrome
title_full_unstemmed Evidence for a heritable predisposition to Chronic Fatigue Syndrome
title_short Evidence for a heritable predisposition to Chronic Fatigue Syndrome
title_sort evidence for a heritable predisposition to chronic fatigue syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128000/
https://www.ncbi.nlm.nih.gov/pubmed/21619629
http://dx.doi.org/10.1186/1471-2377-11-62
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