Maps of Open Chromatin Guide the Functional Follow-Up of Genome-Wide Association Signals: Application to Hematological Traits

Turning genetic discoveries identified in genome-wide association (GWA) studies into biological mechanisms is an important challenge in human genetics. Many GWA signals map outside exons, suggesting that the associated variants may lie within regulatory regions. We applied the formaldehyde-assisted...

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Detalles Bibliográficos
Autores principales: Paul, Dirk S., Nisbet, James P., Yang, Tsun-Po, Meacham, Stuart, Rendon, Augusto, Hautaviita, Katta, Tallila, Jonna, White, Jacqui, Tijssen, Marloes R., Sivapalaratnam, Suthesh, Basart, Hanneke, Trip, Mieke D., Göttgens, Berthold, Soranzo, Nicole, Ouwehand, Willem H., Deloukas, Panos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128100/
https://www.ncbi.nlm.nih.gov/pubmed/21738486
http://dx.doi.org/10.1371/journal.pgen.1002139

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