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The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton

We identify a new pathway that is required for proper pseudopod formation. We show that Roco2, a leucine-rich repeat kinase 2 (LRRK2)-related Roco kinase, is activated in response to chemoattractant stimulation and helps mediate cell polarization and chemotaxis by regulating cortical F-actin polymer...

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Detalles Bibliográficos
Autores principales:	Kicka, Sebastian, Shen, Zhouxin, Annesley, Sarah J., Fisher, Paul R., Lee, Susan, Briggs, Steven, Firtel, Richard A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128523/ https://www.ncbi.nlm.nih.gov/pubmed/21551065 http://dx.doi.org/10.1091/mbc.E10-12-0937

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