Cargando…

cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites

Cutaneous T-cell lymphoma-–associated antigen 5 (cTAGE5), an originally identified tumor antigen, is overexpressed in various cancer cell lines. The cDNA encodes an integral membrane protein containing two coiled-coil motifs and a proline-rich domain. We show that cTAGE5 specifically localizes to th...

Descripción completa

Detalles Bibliográficos
Autores principales: Saito, Kota, Yamashiro, Koh, Ichikawa, Yuki, Erlmann, Patrik, Kontani, Kenji, Malhotra, Vivek, Katada, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128532/
https://www.ncbi.nlm.nih.gov/pubmed/21525241
http://dx.doi.org/10.1091/mbc.E11-02-0143
_version_ 1782207447106060288
author Saito, Kota
Yamashiro, Koh
Ichikawa, Yuki
Erlmann, Patrik
Kontani, Kenji
Malhotra, Vivek
Katada, Toshiaki
author_facet Saito, Kota
Yamashiro, Koh
Ichikawa, Yuki
Erlmann, Patrik
Kontani, Kenji
Malhotra, Vivek
Katada, Toshiaki
author_sort Saito, Kota
collection PubMed
description Cutaneous T-cell lymphoma-–associated antigen 5 (cTAGE5), an originally identified tumor antigen, is overexpressed in various cancer cell lines. The cDNA encodes an integral membrane protein containing two coiled-coil motifs and a proline-rich domain. We show that cTAGE5 specifically localizes to the endoplasmic reticulum (ER) exit sites. In addition, cTAGE5 forms a complex with TANGO1 (MIA3), a previously characterized cargo receptor for collagen VII, by the interaction of their coiled-coil motifs. Of interest, cTAGE5, as well as TANGO1, is capable of interacting with the inner-layer coatomer of COPII Sec23/24 complex through their C-terminal proline-rich domains and required for collagen VII secretion. We propose that cTAGE5 acts as a coreceptor of TANGO1 for collagen VII export from the ER.
format Online
Article
Text
id pubmed-3128532
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher The American Society for Cell Biology
record_format MEDLINE/PubMed
spelling pubmed-31285322011-09-16 cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites Saito, Kota Yamashiro, Koh Ichikawa, Yuki Erlmann, Patrik Kontani, Kenji Malhotra, Vivek Katada, Toshiaki Mol Biol Cell Articles Cutaneous T-cell lymphoma-–associated antigen 5 (cTAGE5), an originally identified tumor antigen, is overexpressed in various cancer cell lines. The cDNA encodes an integral membrane protein containing two coiled-coil motifs and a proline-rich domain. We show that cTAGE5 specifically localizes to the endoplasmic reticulum (ER) exit sites. In addition, cTAGE5 forms a complex with TANGO1 (MIA3), a previously characterized cargo receptor for collagen VII, by the interaction of their coiled-coil motifs. Of interest, cTAGE5, as well as TANGO1, is capable of interacting with the inner-layer coatomer of COPII Sec23/24 complex through their C-terminal proline-rich domains and required for collagen VII secretion. We propose that cTAGE5 acts as a coreceptor of TANGO1 for collagen VII export from the ER. The American Society for Cell Biology 2011-07-01 /pmc/articles/PMC3128532/ /pubmed/21525241 http://dx.doi.org/10.1091/mbc.E11-02-0143 Text en © 2011 Saito et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology.
spellingShingle Articles
Saito, Kota
Yamashiro, Koh
Ichikawa, Yuki
Erlmann, Patrik
Kontani, Kenji
Malhotra, Vivek
Katada, Toshiaki
cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites
title cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites
title_full cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites
title_fullStr cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites
title_full_unstemmed cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites
title_short cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites
title_sort ctage5 mediates collagen secretion through interaction with tango1 at endoplasmic reticulum exit sites
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128532/
https://www.ncbi.nlm.nih.gov/pubmed/21525241
http://dx.doi.org/10.1091/mbc.E11-02-0143
work_keys_str_mv AT saitokota ctage5mediatescollagensecretionthroughinteractionwithtango1atendoplasmicreticulumexitsites
AT yamashirokoh ctage5mediatescollagensecretionthroughinteractionwithtango1atendoplasmicreticulumexitsites
AT ichikawayuki ctage5mediatescollagensecretionthroughinteractionwithtango1atendoplasmicreticulumexitsites
AT erlmannpatrik ctage5mediatescollagensecretionthroughinteractionwithtango1atendoplasmicreticulumexitsites
AT kontanikenji ctage5mediatescollagensecretionthroughinteractionwithtango1atendoplasmicreticulumexitsites
AT malhotravivek ctage5mediatescollagensecretionthroughinteractionwithtango1atendoplasmicreticulumexitsites
AT katadatoshiaki ctage5mediatescollagensecretionthroughinteractionwithtango1atendoplasmicreticulumexitsites