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cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites
Cutaneous T-cell lymphoma-–associated antigen 5 (cTAGE5), an originally identified tumor antigen, is overexpressed in various cancer cell lines. The cDNA encodes an integral membrane protein containing two coiled-coil motifs and a proline-rich domain. We show that cTAGE5 specifically localizes to th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128532/ https://www.ncbi.nlm.nih.gov/pubmed/21525241 http://dx.doi.org/10.1091/mbc.E11-02-0143 |
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author | Saito, Kota Yamashiro, Koh Ichikawa, Yuki Erlmann, Patrik Kontani, Kenji Malhotra, Vivek Katada, Toshiaki |
author_facet | Saito, Kota Yamashiro, Koh Ichikawa, Yuki Erlmann, Patrik Kontani, Kenji Malhotra, Vivek Katada, Toshiaki |
author_sort | Saito, Kota |
collection | PubMed |
description | Cutaneous T-cell lymphoma-–associated antigen 5 (cTAGE5), an originally identified tumor antigen, is overexpressed in various cancer cell lines. The cDNA encodes an integral membrane protein containing two coiled-coil motifs and a proline-rich domain. We show that cTAGE5 specifically localizes to the endoplasmic reticulum (ER) exit sites. In addition, cTAGE5 forms a complex with TANGO1 (MIA3), a previously characterized cargo receptor for collagen VII, by the interaction of their coiled-coil motifs. Of interest, cTAGE5, as well as TANGO1, is capable of interacting with the inner-layer coatomer of COPII Sec23/24 complex through their C-terminal proline-rich domains and required for collagen VII secretion. We propose that cTAGE5 acts as a coreceptor of TANGO1 for collagen VII export from the ER. |
format | Online Article Text |
id | pubmed-3128532 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-31285322011-09-16 cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites Saito, Kota Yamashiro, Koh Ichikawa, Yuki Erlmann, Patrik Kontani, Kenji Malhotra, Vivek Katada, Toshiaki Mol Biol Cell Articles Cutaneous T-cell lymphoma-–associated antigen 5 (cTAGE5), an originally identified tumor antigen, is overexpressed in various cancer cell lines. The cDNA encodes an integral membrane protein containing two coiled-coil motifs and a proline-rich domain. We show that cTAGE5 specifically localizes to the endoplasmic reticulum (ER) exit sites. In addition, cTAGE5 forms a complex with TANGO1 (MIA3), a previously characterized cargo receptor for collagen VII, by the interaction of their coiled-coil motifs. Of interest, cTAGE5, as well as TANGO1, is capable of interacting with the inner-layer coatomer of COPII Sec23/24 complex through their C-terminal proline-rich domains and required for collagen VII secretion. We propose that cTAGE5 acts as a coreceptor of TANGO1 for collagen VII export from the ER. The American Society for Cell Biology 2011-07-01 /pmc/articles/PMC3128532/ /pubmed/21525241 http://dx.doi.org/10.1091/mbc.E11-02-0143 Text en © 2011 Saito et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology. |
spellingShingle | Articles Saito, Kota Yamashiro, Koh Ichikawa, Yuki Erlmann, Patrik Kontani, Kenji Malhotra, Vivek Katada, Toshiaki cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites |
title | cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites |
title_full | cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites |
title_fullStr | cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites |
title_full_unstemmed | cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites |
title_short | cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites |
title_sort | ctage5 mediates collagen secretion through interaction with tango1 at endoplasmic reticulum exit sites |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128532/ https://www.ncbi.nlm.nih.gov/pubmed/21525241 http://dx.doi.org/10.1091/mbc.E11-02-0143 |
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