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Exposed hydrophobicity is a key determinant of nuclear quality control degradation

Protein quality control (PQC) degradation protects the cell by preventing the toxic accumulation of misfolded proteins. In eukaryotes, PQC degradation is primarily achieved by ubiquitin ligases that attach ubiquitin to misfolded proteins for proteasome degradation. To function effectively, PQC ubiqu...

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Detalles Bibliográficos
Autores principales:	Fredrickson, Eric K., Rosenbaum, Joel C., Locke, Melissa N., Milac, Thomas I., Gardner, Richard G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128539/ https://www.ncbi.nlm.nih.gov/pubmed/21551067 http://dx.doi.org/10.1091/mbc.E11-03-0256

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