Lipid Modifications of Sonic Hedgehog Ligand Dictate Cellular Reception and Signal Response

BACKGROUND: Sonic hedgehog (Shh) signaling regulates cell growth during embryonic development, tissue homeostasis and tumorigenesis. Concentration-dependent cellular responses to secreted Shh protein are essential for tissue patterning. Shh ligand is covalently modified by two lipid moieties, choles...

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Detalles Bibliográficos
Autores principales: Grover, Vandana K., Valadez, J. Gerardo, Bowman, Aaron B., Cooper, Michael K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128587/
https://www.ncbi.nlm.nih.gov/pubmed/21747935
http://dx.doi.org/10.1371/journal.pone.0021353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128587/
https://www.ncbi.nlm.nih.gov/pubmed/21747935
http://dx.doi.org/10.1371/journal.pone.0021353

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