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Lipid Modifications of Sonic Hedgehog Ligand Dictate Cellular Reception and Signal Response
BACKGROUND: Sonic hedgehog (Shh) signaling regulates cell growth during embryonic development, tissue homeostasis and tumorigenesis. Concentration-dependent cellular responses to secreted Shh protein are essential for tissue patterning. Shh ligand is covalently modified by two lipid moieties, choles...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128587/ https://www.ncbi.nlm.nih.gov/pubmed/21747935 http://dx.doi.org/10.1371/journal.pone.0021353 |