Knock-Down of Cathepsin D Affects the Retinal Pigment Epithelium, Impairs Swim-Bladder Ontogenesis and Causes Premature Death in Zebrafish

The lysosomal aspartic protease Cathepsin D (CD) is ubiquitously expressed in eukaryotic organisms. CD activity is essential to accomplish the acid-dependent extensive or partial proteolysis of protein substrates within endosomal and lysosomal compartments therein delivered via endocytosis, phagocyt...

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Detalles Bibliográficos
Autores principales: Follo, Carlo, Ozzano, Matteo, Mugoni, Vera, Castino, Roberta, Santoro, Massimo, Isidoro, Ciro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128622/
https://www.ncbi.nlm.nih.gov/pubmed/21747967
http://dx.doi.org/10.1371/journal.pone.0021908

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