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Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease
BACKGROUND: Celiac disease (CD) is an autoimmune disease that develops in patients with a genetic predisposition, incurring a susceptibility to gluten-containing foods such as barley, wheat, and rye. The elimination of gluten from the diet is the main therapeutic approach and usually leads to clinic...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Informa Healthcare
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128725/ https://www.ncbi.nlm.nih.gov/pubmed/21679011 http://dx.doi.org/10.3109/03009734.2011.581399 |
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author | Purnak, Tugrul Efe, Cumali Yuksel, Osman Beyazit, Yavuz Ozaslan, Ersan Altiparmak, Emin |
author_facet | Purnak, Tugrul Efe, Cumali Yuksel, Osman Beyazit, Yavuz Ozaslan, Ersan Altiparmak, Emin |
author_sort | Purnak, Tugrul |
collection | PubMed |
description | BACKGROUND: Celiac disease (CD) is an autoimmune disease that develops in patients with a genetic predisposition, incurring a susceptibility to gluten-containing foods such as barley, wheat, and rye. The elimination of gluten from the diet is the main therapeutic approach and usually leads to clinical and laboratory improvement. There are no ideal markers that objectively assess dietary compliance in CD patients. MATERIALS AND METHODS: Sixty newly diagnosed CD patients (male/female: 43/17) and 40 healthy subjects (male/female: 23/17) were enrolled in this study. The diagnosis of CD was established by both histological findings of duodenum biopsy (total villous atrophy and lymphocytic infiltration) and positive antibodies against endomysium or gliadin. RESULTS: A significantly higher mean platelet volume (MPV) was observed in the CD group compared with healthy subjects (8.45 ± 0.96 fL versus 7.93 ± 0.63 fL; p = 0.004). After introduction of a gluten-free diet, the MPV of CD patients in the dietary adherent group was significantly lower than that of the non-adherent group (8.09 ± 0.6 fL versus 8.9 ± 1.08 fL; p = 0.001). Overall dietary adherence rate was 71.6% (43/60 CD patients). In the dietary compliant group, initiation of gluten-free diet was associated with a significant decrease in MPV from base-line values (8.56 fL versus 8.25 fL; p = 0.008). In the non-adherent group, MPV on 3-month follow-up was higher than at base-line (8.05 fL versus 8.91 fL; p = 0.001). CONCLUSION: MPV could be a promising and easily available biomarker for monitoring of dietary adherence in CD patients at a low cost in comparison with other modalities. |
format | Online Article Text |
id | pubmed-3128725 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Informa Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-31287252011-09-30 Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease Purnak, Tugrul Efe, Cumali Yuksel, Osman Beyazit, Yavuz Ozaslan, Ersan Altiparmak, Emin Ups J Med Sci Original Article BACKGROUND: Celiac disease (CD) is an autoimmune disease that develops in patients with a genetic predisposition, incurring a susceptibility to gluten-containing foods such as barley, wheat, and rye. The elimination of gluten from the diet is the main therapeutic approach and usually leads to clinical and laboratory improvement. There are no ideal markers that objectively assess dietary compliance in CD patients. MATERIALS AND METHODS: Sixty newly diagnosed CD patients (male/female: 43/17) and 40 healthy subjects (male/female: 23/17) were enrolled in this study. The diagnosis of CD was established by both histological findings of duodenum biopsy (total villous atrophy and lymphocytic infiltration) and positive antibodies against endomysium or gliadin. RESULTS: A significantly higher mean platelet volume (MPV) was observed in the CD group compared with healthy subjects (8.45 ± 0.96 fL versus 7.93 ± 0.63 fL; p = 0.004). After introduction of a gluten-free diet, the MPV of CD patients in the dietary adherent group was significantly lower than that of the non-adherent group (8.09 ± 0.6 fL versus 8.9 ± 1.08 fL; p = 0.001). Overall dietary adherence rate was 71.6% (43/60 CD patients). In the dietary compliant group, initiation of gluten-free diet was associated with a significant decrease in MPV from base-line values (8.56 fL versus 8.25 fL; p = 0.008). In the non-adherent group, MPV on 3-month follow-up was higher than at base-line (8.05 fL versus 8.91 fL; p = 0.001). CONCLUSION: MPV could be a promising and easily available biomarker for monitoring of dietary adherence in CD patients at a low cost in comparison with other modalities. Informa Healthcare 2011-08 2011-06-29 /pmc/articles/PMC3128725/ /pubmed/21679011 http://dx.doi.org/10.3109/03009734.2011.581399 Text en © Upsala Medical Society http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited. |
spellingShingle | Original Article Purnak, Tugrul Efe, Cumali Yuksel, Osman Beyazit, Yavuz Ozaslan, Ersan Altiparmak, Emin Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease |
title | Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease |
title_full | Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease |
title_fullStr | Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease |
title_full_unstemmed | Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease |
title_short | Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease |
title_sort | mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128725/ https://www.ncbi.nlm.nih.gov/pubmed/21679011 http://dx.doi.org/10.3109/03009734.2011.581399 |
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