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Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease

BACKGROUND: Celiac disease (CD) is an autoimmune disease that develops in patients with a genetic predisposition, incurring a susceptibility to gluten-containing foods such as barley, wheat, and rye. The elimination of gluten from the diet is the main therapeutic approach and usually leads to clinic...

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Autores principales: Purnak, Tugrul, Efe, Cumali, Yuksel, Osman, Beyazit, Yavuz, Ozaslan, Ersan, Altiparmak, Emin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128725/
https://www.ncbi.nlm.nih.gov/pubmed/21679011
http://dx.doi.org/10.3109/03009734.2011.581399
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author Purnak, Tugrul
Efe, Cumali
Yuksel, Osman
Beyazit, Yavuz
Ozaslan, Ersan
Altiparmak, Emin
author_facet Purnak, Tugrul
Efe, Cumali
Yuksel, Osman
Beyazit, Yavuz
Ozaslan, Ersan
Altiparmak, Emin
author_sort Purnak, Tugrul
collection PubMed
description BACKGROUND: Celiac disease (CD) is an autoimmune disease that develops in patients with a genetic predisposition, incurring a susceptibility to gluten-containing foods such as barley, wheat, and rye. The elimination of gluten from the diet is the main therapeutic approach and usually leads to clinical and laboratory improvement. There are no ideal markers that objectively assess dietary compliance in CD patients. MATERIALS AND METHODS: Sixty newly diagnosed CD patients (male/female: 43/17) and 40 healthy subjects (male/female: 23/17) were enrolled in this study. The diagnosis of CD was established by both histological findings of duodenum biopsy (total villous atrophy and lymphocytic infiltration) and positive antibodies against endomysium or gliadin. RESULTS: A significantly higher mean platelet volume (MPV) was observed in the CD group compared with healthy subjects (8.45 ± 0.96 fL versus 7.93 ± 0.63 fL; p = 0.004). After introduction of a gluten-free diet, the MPV of CD patients in the dietary adherent group was significantly lower than that of the non-adherent group (8.09 ± 0.6 fL versus 8.9 ± 1.08 fL; p = 0.001). Overall dietary adherence rate was 71.6% (43/60 CD patients). In the dietary compliant group, initiation of gluten-free diet was associated with a significant decrease in MPV from base-line values (8.56 fL versus 8.25 fL; p = 0.008). In the non-adherent group, MPV on 3-month follow-up was higher than at base-line (8.05 fL versus 8.91 fL; p = 0.001). CONCLUSION: MPV could be a promising and easily available biomarker for monitoring of dietary adherence in CD patients at a low cost in comparison with other modalities.
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spelling pubmed-31287252011-09-30 Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease Purnak, Tugrul Efe, Cumali Yuksel, Osman Beyazit, Yavuz Ozaslan, Ersan Altiparmak, Emin Ups J Med Sci Original Article BACKGROUND: Celiac disease (CD) is an autoimmune disease that develops in patients with a genetic predisposition, incurring a susceptibility to gluten-containing foods such as barley, wheat, and rye. The elimination of gluten from the diet is the main therapeutic approach and usually leads to clinical and laboratory improvement. There are no ideal markers that objectively assess dietary compliance in CD patients. MATERIALS AND METHODS: Sixty newly diagnosed CD patients (male/female: 43/17) and 40 healthy subjects (male/female: 23/17) were enrolled in this study. The diagnosis of CD was established by both histological findings of duodenum biopsy (total villous atrophy and lymphocytic infiltration) and positive antibodies against endomysium or gliadin. RESULTS: A significantly higher mean platelet volume (MPV) was observed in the CD group compared with healthy subjects (8.45 ± 0.96 fL versus 7.93 ± 0.63 fL; p = 0.004). After introduction of a gluten-free diet, the MPV of CD patients in the dietary adherent group was significantly lower than that of the non-adherent group (8.09 ± 0.6 fL versus 8.9 ± 1.08 fL; p = 0.001). Overall dietary adherence rate was 71.6% (43/60 CD patients). In the dietary compliant group, initiation of gluten-free diet was associated with a significant decrease in MPV from base-line values (8.56 fL versus 8.25 fL; p = 0.008). In the non-adherent group, MPV on 3-month follow-up was higher than at base-line (8.05 fL versus 8.91 fL; p = 0.001). CONCLUSION: MPV could be a promising and easily available biomarker for monitoring of dietary adherence in CD patients at a low cost in comparison with other modalities. Informa Healthcare 2011-08 2011-06-29 /pmc/articles/PMC3128725/ /pubmed/21679011 http://dx.doi.org/10.3109/03009734.2011.581399 Text en © Upsala Medical Society http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Original Article
Purnak, Tugrul
Efe, Cumali
Yuksel, Osman
Beyazit, Yavuz
Ozaslan, Ersan
Altiparmak, Emin
Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease
title Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease
title_full Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease
title_fullStr Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease
title_full_unstemmed Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease
title_short Mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease
title_sort mean platelet volume could be a promising biomarker to monitor dietary compliance in celiac disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128725/
https://www.ncbi.nlm.nih.gov/pubmed/21679011
http://dx.doi.org/10.3109/03009734.2011.581399
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