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Claudins in lung diseases
Tight junctions are the most apically localized part of the epithelial junctional complex. They regulate the permeability and polarity of cell layers and create compartments in cell membranes. Claudins are structural molecules of tight junctions. There are 27 claudins known, and expression of differ...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128860/ https://www.ncbi.nlm.nih.gov/pubmed/21619599 http://dx.doi.org/10.1186/1465-9921-12-70 |
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author | Soini, Ylermi |
author_facet | Soini, Ylermi |
author_sort | Soini, Ylermi |
collection | PubMed |
description | Tight junctions are the most apically localized part of the epithelial junctional complex. They regulate the permeability and polarity of cell layers and create compartments in cell membranes. Claudins are structural molecules of tight junctions. There are 27 claudins known, and expression of different claudins is responsible for changes in the electrolyte and solute permeability in cells layers. Studies have shown that claudins and tight junctions also protect multicellular organisms from infections and that some infectious agents may use claudins as targets to invade and weaken the host's defense. In neoplastic diseases, claudin expression may be up- or downregulated. Since their expression is associated with specific tumor types or with specific locations of tumors to a certain degree, they can, in a restricted sense, also be used as tumor markers. However, the regulation of claudin expression is complex involving growth factors and integrins, protein kinases, proto-oncogens and transcription factors. In this review, the significance of claudins is discussed in lung disease and development. |
format | Online Article Text |
id | pubmed-3128860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31288602011-07-04 Claudins in lung diseases Soini, Ylermi Respir Res Review Tight junctions are the most apically localized part of the epithelial junctional complex. They regulate the permeability and polarity of cell layers and create compartments in cell membranes. Claudins are structural molecules of tight junctions. There are 27 claudins known, and expression of different claudins is responsible for changes in the electrolyte and solute permeability in cells layers. Studies have shown that claudins and tight junctions also protect multicellular organisms from infections and that some infectious agents may use claudins as targets to invade and weaken the host's defense. In neoplastic diseases, claudin expression may be up- or downregulated. Since their expression is associated with specific tumor types or with specific locations of tumors to a certain degree, they can, in a restricted sense, also be used as tumor markers. However, the regulation of claudin expression is complex involving growth factors and integrins, protein kinases, proto-oncogens and transcription factors. In this review, the significance of claudins is discussed in lung disease and development. BioMed Central 2011 2011-05-27 /pmc/articles/PMC3128860/ /pubmed/21619599 http://dx.doi.org/10.1186/1465-9921-12-70 Text en Copyright ©2011 Soini; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Soini, Ylermi Claudins in lung diseases |
title | Claudins in lung diseases |
title_full | Claudins in lung diseases |
title_fullStr | Claudins in lung diseases |
title_full_unstemmed | Claudins in lung diseases |
title_short | Claudins in lung diseases |
title_sort | claudins in lung diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128860/ https://www.ncbi.nlm.nih.gov/pubmed/21619599 http://dx.doi.org/10.1186/1465-9921-12-70 |
work_keys_str_mv | AT soiniylermi claudinsinlungdiseases |