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Clinical outcomes of Torque teno virus-infected thalassemic patients with and without hepatitis C virus infection

BACKGROUND: Although a marked proportion of thalassemic patients acquire Torque teno virus (TTV) through blood transfusion, its clinical importance is unclear. This study was designed to investigate the clinical importance of TTV infection in thalassemic patients with and without hepatitis C virus (...

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Autores principales: Alavi, Samin, Sharifi, Zohreh, Valeshabad, Ali Kord, Nourbakhsh, Kazem, Shamsian, Bibi Shahin, Arzanian, Mohammad Taghi, Safarisharari, Alieh, Navidinia, Masoumeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128893/
https://www.ncbi.nlm.nih.gov/pubmed/21747885
http://dx.doi.org/10.5045/kjh.2011.46.2.123
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author Alavi, Samin
Sharifi, Zohreh
Valeshabad, Ali Kord
Nourbakhsh, Kazem
Shamsian, Bibi Shahin
Arzanian, Mohammad Taghi
Safarisharari, Alieh
Navidinia, Masoumeh
author_facet Alavi, Samin
Sharifi, Zohreh
Valeshabad, Ali Kord
Nourbakhsh, Kazem
Shamsian, Bibi Shahin
Arzanian, Mohammad Taghi
Safarisharari, Alieh
Navidinia, Masoumeh
author_sort Alavi, Samin
collection PubMed
description BACKGROUND: Although a marked proportion of thalassemic patients acquire Torque teno virus (TTV) through blood transfusion, its clinical importance is unclear. This study was designed to investigate the clinical importance of TTV infection in thalassemic patients with and without hepatitis C virus (HCV) co-infection in Iran. METHODS: In this case-control study, 107 thalassemic patients on chronic transfusion and 107 healthy individuals were selected. According to HCV and TTV infection status (detected by semi-nested PCR), patients were categorized into 4 groups: TTV and HCV negative, TTV positive, HCV positive, and TTV and HCV positive. Blood ferritin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels in these 4 groups were assessed. RESULTS: Approximately half of the thalassemic patients (50.5%) and 27.1% of controls had TTV infection. Thalassemic patients had a greater chance of TTV infection compared to the control group with a sex-adjusted OR of 4.13 (95% CI=2.28-8.13). The increased levels of ALT, AST, and ferritin in the TTV and HCV-infected group were not significantly different from those in the TTV and HCV negative group. Co-infection with TTV and HCV did not significantly increase ALT, AST, and ferritin levels compared to infection with TTV alone. CONCLUSION: Although common in thalassemic patients, TTV infection appears to have a negligible role in increasing the severity of liver disease, even when co-infection with HCV occurs.
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spelling pubmed-31288932011-07-11 Clinical outcomes of Torque teno virus-infected thalassemic patients with and without hepatitis C virus infection Alavi, Samin Sharifi, Zohreh Valeshabad, Ali Kord Nourbakhsh, Kazem Shamsian, Bibi Shahin Arzanian, Mohammad Taghi Safarisharari, Alieh Navidinia, Masoumeh Korean J Hematol Original Article BACKGROUND: Although a marked proportion of thalassemic patients acquire Torque teno virus (TTV) through blood transfusion, its clinical importance is unclear. This study was designed to investigate the clinical importance of TTV infection in thalassemic patients with and without hepatitis C virus (HCV) co-infection in Iran. METHODS: In this case-control study, 107 thalassemic patients on chronic transfusion and 107 healthy individuals were selected. According to HCV and TTV infection status (detected by semi-nested PCR), patients were categorized into 4 groups: TTV and HCV negative, TTV positive, HCV positive, and TTV and HCV positive. Blood ferritin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels in these 4 groups were assessed. RESULTS: Approximately half of the thalassemic patients (50.5%) and 27.1% of controls had TTV infection. Thalassemic patients had a greater chance of TTV infection compared to the control group with a sex-adjusted OR of 4.13 (95% CI=2.28-8.13). The increased levels of ALT, AST, and ferritin in the TTV and HCV-infected group were not significantly different from those in the TTV and HCV negative group. Co-infection with TTV and HCV did not significantly increase ALT, AST, and ferritin levels compared to infection with TTV alone. CONCLUSION: Although common in thalassemic patients, TTV infection appears to have a negligible role in increasing the severity of liver disease, even when co-infection with HCV occurs. Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2011-06 2011-06-21 /pmc/articles/PMC3128893/ /pubmed/21747885 http://dx.doi.org/10.5045/kjh.2011.46.2.123 Text en © 2011 Korean Society of Hematology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Alavi, Samin
Sharifi, Zohreh
Valeshabad, Ali Kord
Nourbakhsh, Kazem
Shamsian, Bibi Shahin
Arzanian, Mohammad Taghi
Safarisharari, Alieh
Navidinia, Masoumeh
Clinical outcomes of Torque teno virus-infected thalassemic patients with and without hepatitis C virus infection
title Clinical outcomes of Torque teno virus-infected thalassemic patients with and without hepatitis C virus infection
title_full Clinical outcomes of Torque teno virus-infected thalassemic patients with and without hepatitis C virus infection
title_fullStr Clinical outcomes of Torque teno virus-infected thalassemic patients with and without hepatitis C virus infection
title_full_unstemmed Clinical outcomes of Torque teno virus-infected thalassemic patients with and without hepatitis C virus infection
title_short Clinical outcomes of Torque teno virus-infected thalassemic patients with and without hepatitis C virus infection
title_sort clinical outcomes of torque teno virus-infected thalassemic patients with and without hepatitis c virus infection
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128893/
https://www.ncbi.nlm.nih.gov/pubmed/21747885
http://dx.doi.org/10.5045/kjh.2011.46.2.123
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