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Successful treatment with erythromycin for idiopathic thrombocytopenic purpura

Macrolides have both immunomodulatory and antibacterial effects. We report 3 cases of primary immune thrombocytopenia (ITP) patients who were successfully treated with macrolides, irrespective of Helicobacter pylori (H. pylori) infection status. Case 1, an 88-year-old woman who was an H. pylori-posi...

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Autores principales: Ohe, Masashi, Hashino, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128896/
https://www.ncbi.nlm.nih.gov/pubmed/21747888
http://dx.doi.org/10.5045/kjh.2011.46.2.139
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author Ohe, Masashi
Hashino, Satoshi
author_facet Ohe, Masashi
Hashino, Satoshi
author_sort Ohe, Masashi
collection PubMed
description Macrolides have both immunomodulatory and antibacterial effects. We report 3 cases of primary immune thrombocytopenia (ITP) patients who were successfully treated with macrolides, irrespective of Helicobacter pylori (H. pylori) infection status. Case 1, an 88-year-old woman who was an H. pylori-positive ITP patient, was treated with clarithromycin (CAM). CAM was effective temporarily. As an alternative to CAM, she was successfully treated with erythromycin (EM) for more than 7 months. Case 2, a 61-year-old man who was an H. pylori-negative ITP patient, was unsuccessfully treated with CAM but successfully treated with EM. Case 3, a 75-year-old woman who was a H. pylori-negative ITP patient, was treated with CAM. CAM was effective temporarily. After approximately 6 months, she was treated with EM for a common cold, and her platelet count increased rapidly. Based on these findings, macrolide treatment was effective for ITP. The effectiveness of macrolides might suggest immunomodulatory effects as well as antibacterial effects for H. pylori.
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spelling pubmed-31288962011-07-11 Successful treatment with erythromycin for idiopathic thrombocytopenic purpura Ohe, Masashi Hashino, Satoshi Korean J Hematol Case Report Macrolides have both immunomodulatory and antibacterial effects. We report 3 cases of primary immune thrombocytopenia (ITP) patients who were successfully treated with macrolides, irrespective of Helicobacter pylori (H. pylori) infection status. Case 1, an 88-year-old woman who was an H. pylori-positive ITP patient, was treated with clarithromycin (CAM). CAM was effective temporarily. As an alternative to CAM, she was successfully treated with erythromycin (EM) for more than 7 months. Case 2, a 61-year-old man who was an H. pylori-negative ITP patient, was unsuccessfully treated with CAM but successfully treated with EM. Case 3, a 75-year-old woman who was a H. pylori-negative ITP patient, was treated with CAM. CAM was effective temporarily. After approximately 6 months, she was treated with EM for a common cold, and her platelet count increased rapidly. Based on these findings, macrolide treatment was effective for ITP. The effectiveness of macrolides might suggest immunomodulatory effects as well as antibacterial effects for H. pylori. Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2011-06 2011-06-21 /pmc/articles/PMC3128896/ /pubmed/21747888 http://dx.doi.org/10.5045/kjh.2011.46.2.139 Text en © 2011 Korean Society of Hematology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ohe, Masashi
Hashino, Satoshi
Successful treatment with erythromycin for idiopathic thrombocytopenic purpura
title Successful treatment with erythromycin for idiopathic thrombocytopenic purpura
title_full Successful treatment with erythromycin for idiopathic thrombocytopenic purpura
title_fullStr Successful treatment with erythromycin for idiopathic thrombocytopenic purpura
title_full_unstemmed Successful treatment with erythromycin for idiopathic thrombocytopenic purpura
title_short Successful treatment with erythromycin for idiopathic thrombocytopenic purpura
title_sort successful treatment with erythromycin for idiopathic thrombocytopenic purpura
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128896/
https://www.ncbi.nlm.nih.gov/pubmed/21747888
http://dx.doi.org/10.5045/kjh.2011.46.2.139
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