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Neighboring Pallidal Neurons Do Not Exhibit more Synchronous Oscillations than Remote Ones in the MPTP Primate Model of Parkinson's Disease

In the healthy primate, neurons of the external and internal segments of the globus pallidus (GP) present a primarily irregular firing pattern, and a negligible level of synchrony is observed between pairs of neurons. This holds even for neighboring cells, despite their higher probability to receive...

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Autores principales: Mitelman, Rea, Rosin, Boris, Zadka, Hila, Slovik, Maya, Heimer, Gali, Ritov, Ya'akov, Bergman, Hagai, Elias, Shlomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129135/
https://www.ncbi.nlm.nih.gov/pubmed/21747760
http://dx.doi.org/10.3389/fnsys.2011.00054
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author Mitelman, Rea
Rosin, Boris
Zadka, Hila
Slovik, Maya
Heimer, Gali
Ritov, Ya'akov
Bergman, Hagai
Elias, Shlomo
author_facet Mitelman, Rea
Rosin, Boris
Zadka, Hila
Slovik, Maya
Heimer, Gali
Ritov, Ya'akov
Bergman, Hagai
Elias, Shlomo
author_sort Mitelman, Rea
collection PubMed
description In the healthy primate, neurons of the external and internal segments of the globus pallidus (GP) present a primarily irregular firing pattern, and a negligible level of synchrony is observed between pairs of neurons. This holds even for neighboring cells, despite their higher probability to receive common inputs and to innervate each other via lateral connectivity. In the Parkinsonian primate, this changes drastically, and many pairs of GP cells show synchronous oscillations. To address the relation between distance and synchrony in the Parkinsonian state, we compared the synchrony of discharge of close pairs of neurons, recorded by the same electrode, with remote pairs, recorded by different ones. However, spike trains of neighboring cells recorded by the same extracellular electrode exhibit the shadowing effect; i.e., lack of detection of spikes that occur within a few milliseconds of each other. Here, we demonstrate that the shadowing artifact can both induce apparent correlations between non-correlated neurons, as well as conceal existing correlations between neighboring ones. We therefore introduced artificial shadowing in the remote pairs, similar to the effect we observed in the close ones. After the artificial shadowing, neighboring cells did not show a higher tendency to oscillate synchronously than remote ones. On the contrary, the average percentage (over all sessions) of artificially shadowed remote pairs exhibiting synchronous oscillations was 35.4% compared to 17.2% in the close ones. Similar trend was found when the unshadowed remote pairs were separated according to the estimated distance between electrode tips: 29.9% of pairs at approximate distance of less than 750 μm were significantly synchronized, in comparison with 28.5% of the pairs whose distance was more than 750 μm. We conclude that the synchronous oscillations in the GP of MPTP treated primates are homogenously distributed.
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spelling pubmed-31291352011-07-11 Neighboring Pallidal Neurons Do Not Exhibit more Synchronous Oscillations than Remote Ones in the MPTP Primate Model of Parkinson's Disease Mitelman, Rea Rosin, Boris Zadka, Hila Slovik, Maya Heimer, Gali Ritov, Ya'akov Bergman, Hagai Elias, Shlomo Front Syst Neurosci Neuroscience In the healthy primate, neurons of the external and internal segments of the globus pallidus (GP) present a primarily irregular firing pattern, and a negligible level of synchrony is observed between pairs of neurons. This holds even for neighboring cells, despite their higher probability to receive common inputs and to innervate each other via lateral connectivity. In the Parkinsonian primate, this changes drastically, and many pairs of GP cells show synchronous oscillations. To address the relation between distance and synchrony in the Parkinsonian state, we compared the synchrony of discharge of close pairs of neurons, recorded by the same electrode, with remote pairs, recorded by different ones. However, spike trains of neighboring cells recorded by the same extracellular electrode exhibit the shadowing effect; i.e., lack of detection of spikes that occur within a few milliseconds of each other. Here, we demonstrate that the shadowing artifact can both induce apparent correlations between non-correlated neurons, as well as conceal existing correlations between neighboring ones. We therefore introduced artificial shadowing in the remote pairs, similar to the effect we observed in the close ones. After the artificial shadowing, neighboring cells did not show a higher tendency to oscillate synchronously than remote ones. On the contrary, the average percentage (over all sessions) of artificially shadowed remote pairs exhibiting synchronous oscillations was 35.4% compared to 17.2% in the close ones. Similar trend was found when the unshadowed remote pairs were separated according to the estimated distance between electrode tips: 29.9% of pairs at approximate distance of less than 750 μm were significantly synchronized, in comparison with 28.5% of the pairs whose distance was more than 750 μm. We conclude that the synchronous oscillations in the GP of MPTP treated primates are homogenously distributed. Frontiers Research Foundation 2011-06-30 /pmc/articles/PMC3129135/ /pubmed/21747760 http://dx.doi.org/10.3389/fnsys.2011.00054 Text en Copyright © 2011 Mitelman, Rosin, Zadka, Slovik, Heimer, Ritov, Bergman and Elias. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Neuroscience
Mitelman, Rea
Rosin, Boris
Zadka, Hila
Slovik, Maya
Heimer, Gali
Ritov, Ya'akov
Bergman, Hagai
Elias, Shlomo
Neighboring Pallidal Neurons Do Not Exhibit more Synchronous Oscillations than Remote Ones in the MPTP Primate Model of Parkinson's Disease
title Neighboring Pallidal Neurons Do Not Exhibit more Synchronous Oscillations than Remote Ones in the MPTP Primate Model of Parkinson's Disease
title_full Neighboring Pallidal Neurons Do Not Exhibit more Synchronous Oscillations than Remote Ones in the MPTP Primate Model of Parkinson's Disease
title_fullStr Neighboring Pallidal Neurons Do Not Exhibit more Synchronous Oscillations than Remote Ones in the MPTP Primate Model of Parkinson's Disease
title_full_unstemmed Neighboring Pallidal Neurons Do Not Exhibit more Synchronous Oscillations than Remote Ones in the MPTP Primate Model of Parkinson's Disease
title_short Neighboring Pallidal Neurons Do Not Exhibit more Synchronous Oscillations than Remote Ones in the MPTP Primate Model of Parkinson's Disease
title_sort neighboring pallidal neurons do not exhibit more synchronous oscillations than remote ones in the mptp primate model of parkinson's disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129135/
https://www.ncbi.nlm.nih.gov/pubmed/21747760
http://dx.doi.org/10.3389/fnsys.2011.00054
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