Discovering the Targets of Drugs Via Computational Systems Biology

Computational systems biology is empowering the study of drug action. Studies on biological effects of chemical compounds have increased in scale and accessibility, allowing integration with other large-scale experimental data types. Here, we review computational approaches for elucidating the mecha...

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Detalles Bibliográficos
Autores principales: Chua, Hon Nian, Roth, Frederick P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129145/
https://www.ncbi.nlm.nih.gov/pubmed/21566122
http://dx.doi.org/10.1074/jbc.R110.174797
Descripción
Sumario:Computational systems biology is empowering the study of drug action. Studies on biological effects of chemical compounds have increased in scale and accessibility, allowing integration with other large-scale experimental data types. Here, we review computational approaches for elucidating the mechanisms of both intended and undesirable effects of drugs, with the collective potential to change the nature of drug discovery and pharmacological therapy.

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