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Structure and Mechanism of Human UDP-glucose 6-Dehydrogenase

Elevated production of the matrix glycosaminoglycan hyaluronan is strongly implicated in epithelial tumor progression. Inhibition of synthesis of the hyaluronan precursor UDP-glucuronic acid (UDP-GlcUA) therefore presents an emerging target for cancer therapy. Human UDP-glucose 6-dehydrogenase (hUGD...

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Detalles Bibliográficos
Autores principales:	Egger, Sigrid, Chaikuad, Apirat, Kavanagh, Kathryn L., Oppermann, Udo, Nidetzky, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129169/ https://www.ncbi.nlm.nih.gov/pubmed/21502315 http://dx.doi.org/10.1074/jbc.M111.234682

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