Cargando…

Molecular Recognition of Chymotrypsin by the Serine Protease Inhibitor Ecotin from Yersinia pestis

Resistance to antibiotics is a problem not only in terms of healthcare but also biodefense. Engineering of resistance into a human pathogen could create an untreatable biothreat pathogen. One such pathogen is Yersinia pestis, the causative agent of plague. Previously, we have used a bioinformatic ap...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clark, Elizabeth A., Walker, Nicola, Ford, Donna C., Cooper, Ian A., Oyston, Petra C. F., Acharya, K. Ravi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129183/ https://www.ncbi.nlm.nih.gov/pubmed/21531711 http://dx.doi.org/10.1074/jbc.M111.225730

Ejemplares similares

Structural Insights into the Binding of Vascular Endothelial Growth Factor-B by VEGFR-1(D2): RECOGNITION AND SPECIFICITY
por: Iyer, Shalini, et al.
Publicado: (2010)

Tandem sialoglycan-binding modules in a Streptococcus sanguinis serine-rich repeat adhesin create target dependent avidity effects
por: Stubbs, Haley E., et al.
Publicado: (2020)

Mechanism of the Maturation Process of SARS-CoV 3CL Protease
por: Hsu, Min-Feng, et al.
Publicado: (2005)

Specificity of Staphyloferrin B Recognition by the SirA Receptor from Staphylococcus aureus
por: Grigg, Jason C., et al.
Publicado: (2010)

Dissection Study on the Severe Acute Respiratory Syndrome 3C-like Protease Reveals the Critical Role of the Extra Domain in Dimerization of the Enzyme: DEFINING THE EXTRA DOMAIN AS A NEW TARGET FOR DESIGN OF HIGHLY SPECIFIC PROTEASE INHIBITORS
por: Shi, Jiahai, et al.
Publicado: (2004)

Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity
por: Fieulaine, Sonia, et al.
Publicado: (2020)

Rigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor Triggering
por: Yu, Chao, et al.
Publicado: (2011)

Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3
por: Kim, Sophia, et al.
Publicado: (2016)

The Truncated C-terminal RNA Recognition Motif of TDP-43 Protein Plays a Key Role in Forming Proteinaceous Aggregates
por: Wang, Yi-Ting, et al.
Publicado: (2013)

Structure-specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones
por: Marcianò, Gabriele, et al.
Publicado: (2018)

α(2)-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester
por: Harwood, Seandean Lykke, et al.
Publicado: (2021)

The N Domain of Human Angiotensin-I-converting Enzyme: THE ROLE OF N-GLYCOSYLATION AND THE CRYSTAL STRUCTURE IN COMPLEX WITH AN N DOMAIN-SPECIFIC PHOSPHINIC INHIBITOR, RXP407
por: Anthony, Colin S., et al.
Publicado: (2010)

Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogen Clostridioides difficile
por: Bradshaw, William J., et al.
Publicado: (2019)

Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CL(pro)): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS
por: Tomar, Sakshi, et al.
Publicado: (2015)

Structural Basis of Molecular Recognition of the Leishmania Small Hydrophilic Endoplasmic Reticulum-associated Protein (SHERP) at Membrane Surfaces
por: Moore, Benjamin, et al.
Publicado: (2011)

Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition
por: Dall, Elfriede, et al.
Publicado: (2020)

Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease: CRYSTAL STRUCTURE WITH MOLECULAR DYNAMICS SIMULATIONS
por: Chen, Shuai, et al.
Publicado: (2008)

Atomic Resolution X-ray Structure of the Substrate Recognition Domain of Higher Plant Ribulose-bisphosphate Carboxylase/Oxygenase (Rubisco) Activase
por: Henderson, J. Nathan, et al.
Publicado: (2011)

Solution NMR Analyses of the C-type Carbohydrate Recognition Domain of DC-SIGNR Protein Reveal Different Binding Modes for HIV-derived Oligosaccharides and Smaller Glycan Fragments
por: Probert, Fay, et al.
Publicado: (2013)

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): THREE-DIMENSIONAL STRUCTURE AND LOCALIZATION OF A CHANNEL GATE
por: Rosenberg, Mark F., et al.
Publicado: (2011)

Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR
por: Owen, C. David, et al.
Publicado: (2015)

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin
por: Gingras, Alexandre R., et al.
Publicado: (2010)

Structural Insights into the Autoregulation and Cooperativity of the Human Transcription Factor Ets-2
por: Newman, Joseph A, et al.
Publicado: (2015)

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases
por: Canning, Peter, et al.
Publicado: (2013)

Conserved Distal Loop Residues in the Hsp104 and ClpB Middle Domain Contact Nucleotide-binding Domain 2 and Enable Hsp70-dependent Protein Disaggregation
por: DeSantis, Morgan E., et al.
Publicado: (2014)

Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva
por: Chaikuad, Apirat, et al.
Publicado: (2012)

Computational and structural evidence for neurotransmitter-mediated modulation of the oligomeric states of human insulin in storage granules
por: Palivec, Vladimír, et al.
Publicado: (2017)

Modulating functional amyloid formation via alternative splicing of the premelanosomal protein PMEL17
por: Dean, Dexter N., et al.
Publicado: (2020)

The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease
por: Reijns, Martin A. M., et al.
Publicado: (2011)

Structural Basis of Neutralization by a Human Anti-severe Acute Respiratory Syndrome Spike Protein Antibody, 80R
por: Hwang, William C., et al.
Publicado: (2006)

Structure of the Human 26S Proteasome: SUBUNIT RADIAL DISPLACEMENTS OPEN THE GATE INTO THE PROTEOLYTIC CORE
por: da Fonseca, Paula C. A., et al.
Publicado: (2008)

Structural characterization of anti-CCL5 activity of the tick salivary protein evasin-4
por: Denisov, Stepan S., et al.
Publicado: (2020)

Structural Analysis of the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Intracellular Domain Reveals a Conserved Interaction Epitope
por: Mayer, Christina, et al.
Publicado: (2012)

The Three-dimensional Structure of Carnocyclin A Reveals That Many Circular Bacteriocins Share a Common Structural Motif
por: Martin-Visscher, Leah A., et al.
Publicado: (2009)

Methionine Oxidation of Sup35 Protein Induces Formation of the [PSI(+)] Prion in a Yeast Peroxiredoxin Mutant
por: Sideri, Theodora C., et al.
Publicado: (2011)

Interactions between Kar2p and Its Nucleotide Exchange Factors Sil1p and Lhs1p Are Mechanistically Distinct
por: Hale, Sarah J., et al.
Publicado: (2010)

Structural basis of cell-surface signaling by a conserved sigma regulator in Gram-negative bacteria
por: Jensen, Jaime L., et al.
Publicado: (2020)

Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand
por: Gelinas, Amy D., et al.
Publicado: (2014)

Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015
por: Dagbay, Kevin B., et al.
Publicado: (2020)

Structure of Signal-regulatory Protein α: A LINK TO ANTIGEN RECEPTOR EVOLUTION
por: Hatherley, Deborah, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_u1aaguig2v40flek51uc0bv2p9