Cargando…
Birefringence measurement of the retinal nerve fiber layer by swept source polarization sensitive optical coherence tomography
A Swept Source Polarization-Sensitive Optical Coherence Tomography (SS-PS-OCT) instrument has been designed, constructed, and verified to provide high sensitivity depth-resolved birefringence and phase retardation measurements of the retinal nerve fiber layer. The swept-source laser had a center wav...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Optical Society of America
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129618/ https://www.ncbi.nlm.nih.gov/pubmed/21643283 http://dx.doi.org/10.1364/OE.19.010252 |
_version_ | 1782207548626042880 |
---|---|
author | Elmaanaoui, Badr Wang, Bingqing Dwelle, Jordan C. McElroy, Austin B. Liu, Shuang S. Rylander, Henry G. Milner, Thomas E. |
author_facet | Elmaanaoui, Badr Wang, Bingqing Dwelle, Jordan C. McElroy, Austin B. Liu, Shuang S. Rylander, Henry G. Milner, Thomas E. |
author_sort | Elmaanaoui, Badr |
collection | PubMed |
description | A Swept Source Polarization-Sensitive Optical Coherence Tomography (SS-PS-OCT) instrument has been designed, constructed, and verified to provide high sensitivity depth-resolved birefringence and phase retardation measurements of the retinal nerve fiber layer. The swept-source laser had a center wavelength of 1059 nm, a full-width-half-max spectral bandwidth of 58 nm and an A-line scan rate of 34 KHz. Power incident on the cornea was 440 µW and measured axial resolution was 17 µm in air. A multiple polarization state nonlinear fitting algorithm was used to measure retinal birefringence with low uncertainty. Maps of RNFL phase retardation in a subject measured with SS-PS-OCT compare well with those generated using a commercial scanning laser polarimetry instrument. Peak-to-valley variation of RNFL birefringence given here is less than values previously reported at 840nm. |
format | Online Article Text |
id | pubmed-3129618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-31296182012-05-23 Birefringence measurement of the retinal nerve fiber layer by swept source polarization sensitive optical coherence tomography Elmaanaoui, Badr Wang, Bingqing Dwelle, Jordan C. McElroy, Austin B. Liu, Shuang S. Rylander, Henry G. Milner, Thomas E. Opt Express Research-Article A Swept Source Polarization-Sensitive Optical Coherence Tomography (SS-PS-OCT) instrument has been designed, constructed, and verified to provide high sensitivity depth-resolved birefringence and phase retardation measurements of the retinal nerve fiber layer. The swept-source laser had a center wavelength of 1059 nm, a full-width-half-max spectral bandwidth of 58 nm and an A-line scan rate of 34 KHz. Power incident on the cornea was 440 µW and measured axial resolution was 17 µm in air. A multiple polarization state nonlinear fitting algorithm was used to measure retinal birefringence with low uncertainty. Maps of RNFL phase retardation in a subject measured with SS-PS-OCT compare well with those generated using a commercial scanning laser polarimetry instrument. Peak-to-valley variation of RNFL birefringence given here is less than values previously reported at 840nm. Optical Society of America 2011-05-10 /pmc/articles/PMC3129618/ /pubmed/21643283 http://dx.doi.org/10.1364/OE.19.010252 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. |
spellingShingle | Research-Article Elmaanaoui, Badr Wang, Bingqing Dwelle, Jordan C. McElroy, Austin B. Liu, Shuang S. Rylander, Henry G. Milner, Thomas E. Birefringence measurement of the retinal nerve fiber layer by swept source polarization sensitive optical coherence tomography |
title | Birefringence measurement of the retinal nerve fiber layer by swept source polarization sensitive optical coherence tomography |
title_full | Birefringence measurement of the retinal nerve fiber layer by swept source polarization sensitive optical coherence tomography |
title_fullStr | Birefringence measurement of the retinal nerve fiber layer by swept source polarization sensitive optical coherence tomography |
title_full_unstemmed | Birefringence measurement of the retinal nerve fiber layer by swept source polarization sensitive optical coherence tomography |
title_short | Birefringence measurement of the retinal nerve fiber layer by swept source polarization sensitive optical coherence tomography |
title_sort | birefringence measurement of the retinal nerve fiber layer by swept source polarization sensitive optical coherence tomography |
topic | Research-Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129618/ https://www.ncbi.nlm.nih.gov/pubmed/21643283 http://dx.doi.org/10.1364/OE.19.010252 |
work_keys_str_mv | AT elmaanaouibadr birefringencemeasurementoftheretinalnervefiberlayerbysweptsourcepolarizationsensitiveopticalcoherencetomography AT wangbingqing birefringencemeasurementoftheretinalnervefiberlayerbysweptsourcepolarizationsensitiveopticalcoherencetomography AT dwellejordanc birefringencemeasurementoftheretinalnervefiberlayerbysweptsourcepolarizationsensitiveopticalcoherencetomography AT mcelroyaustinb birefringencemeasurementoftheretinalnervefiberlayerbysweptsourcepolarizationsensitiveopticalcoherencetomography AT liushuangs birefringencemeasurementoftheretinalnervefiberlayerbysweptsourcepolarizationsensitiveopticalcoherencetomography AT rylanderhenryg birefringencemeasurementoftheretinalnervefiberlayerbysweptsourcepolarizationsensitiveopticalcoherencetomography AT milnerthomase birefringencemeasurementoftheretinalnervefiberlayerbysweptsourcepolarizationsensitiveopticalcoherencetomography |