Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidis and human cells

BACKGROUND: Xenobiotics represent an environmental stress and as such are a source for antibiotics, including the isoquinoline (IQ) compound IQ-143. Here, we demonstrate the utility of complementary analysis of both host and pathogen datasets in assessing bacterial adaptation to IQ-143, a synthetic...

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Detalles Bibliográficos
Autores principales: Cecil, Alexander, Rikanović, Carina, Ohlsen, Knut, Liang, Chunguang, Bernhardt, Jörg, Oelschlaeger, Tobias A, Gulder, Tanja, Bringmann, Gerhard, Holzgrabe, Ulrike, Unger, Matthias, Dandekar, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129674/
https://www.ncbi.nlm.nih.gov/pubmed/21418624
http://dx.doi.org/10.1186/gb-2011-12-3-r24

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