Molecular virology of hepatitis E virus

This review details the molecular virology of the hepatitis E virus (HEV). While replicons and in vitro infection systems have recently become available, a lot of information on HEV has been generated through comparisons with better-studied positive-strand RNA viruses and through subgenomic expressi...

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Detalles Bibliográficos
Autores principales: Ahmad, Imran, Holla, R. Prasida, Jameel, Shahid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130092/
https://www.ncbi.nlm.nih.gov/pubmed/21345356
http://dx.doi.org/10.1016/j.virusres.2011.02.011
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author Ahmad, Imran
Holla, R. Prasida
Jameel, Shahid
author_facet Ahmad, Imran
Holla, R. Prasida
Jameel, Shahid
author_sort Ahmad, Imran
collection PubMed
description This review details the molecular virology of the hepatitis E virus (HEV). While replicons and in vitro infection systems have recently become available, a lot of information on HEV has been generated through comparisons with better-studied positive-strand RNA viruses and through subgenomic expression of viral open reading frames. These models are now being verified with replicon and infection systems. We provide here the current knowledge on the HEV genome and its constituent proteins – ORF1, ORF2 and ORF3. Based on the available information, we also modify the existing model of the HEV life cycle.
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spelling pubmed-31300922012-10-01 Molecular virology of hepatitis E virus Ahmad, Imran Holla, R. Prasida Jameel, Shahid Virus Res Review This review details the molecular virology of the hepatitis E virus (HEV). While replicons and in vitro infection systems have recently become available, a lot of information on HEV has been generated through comparisons with better-studied positive-strand RNA viruses and through subgenomic expression of viral open reading frames. These models are now being verified with replicon and infection systems. We provide here the current knowledge on the HEV genome and its constituent proteins – ORF1, ORF2 and ORF3. Based on the available information, we also modify the existing model of the HEV life cycle. Elsevier B.V. 2011-10 2011-02-21 /pmc/articles/PMC3130092/ /pubmed/21345356 http://dx.doi.org/10.1016/j.virusres.2011.02.011 Text en Copyright © 2011 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Ahmad, Imran
Holla, R. Prasida
Jameel, Shahid
Molecular virology of hepatitis E virus
title Molecular virology of hepatitis E virus
title_full Molecular virology of hepatitis E virus
title_fullStr Molecular virology of hepatitis E virus
title_full_unstemmed Molecular virology of hepatitis E virus
title_short Molecular virology of hepatitis E virus
title_sort molecular virology of hepatitis e virus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130092/
https://www.ncbi.nlm.nih.gov/pubmed/21345356
http://dx.doi.org/10.1016/j.virusres.2011.02.011
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