Quantification of lentiviral vector copy numbers in individual hematopoietic colony-forming cells shows vector dose-dependent effects on the frequency and level of transduction

Lentiviral vectors are effective tools for gene transfer and integrate variable numbers of proviral DNA copies in variable proportions of cells. The levels of transduction of a cellular population may therefore depend upon experimental parameters affecting the frequency and/or the distribution of ve...

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Detalles Bibliográficos
Autores principales: Charrier, S, Ferrand, M, Zerbato, M, Précigout, G, Viornery, A, Bucher-Laurent, S, Benkhelifa-Ziyyat, S, Merten, O W, Perea, J, Galy, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130191/
https://www.ncbi.nlm.nih.gov/pubmed/21160533
http://dx.doi.org/10.1038/gt.2010.163

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